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Croatica Chemica Acta, Vol. 89 No. 2, 2016.

Izvorni znanstveni članak
https://doi.org/10.5562/cca2863

Non-linear Optimization of Parameters in Hill Kinetics

Željko Jeričević ; Department of Computer Engineering, Technical Faculty, Vukovarska 58, HR-51000 Rijeka, Croatia

Puni tekst: engleski, pdf (778 KB) str. 213-215 preuzimanja: 1.709* citiraj
APA 6th Edition
Jeričević, Ž. (2016). Non-linear Optimization of Parameters in Hill Kinetics. Croatica Chemica Acta, 89 (2), 213-215. https://doi.org/10.5562/cca2863
MLA 8th Edition
Jeričević, Željko. "Non-linear Optimization of Parameters in Hill Kinetics." Croatica Chemica Acta, vol. 89, br. 2, 2016, str. 213-215. https://doi.org/10.5562/cca2863. Citirano 07.03.2021.
Chicago 17th Edition
Jeričević, Željko. "Non-linear Optimization of Parameters in Hill Kinetics." Croatica Chemica Acta 89, br. 2 (2016): 213-215. https://doi.org/10.5562/cca2863
Harvard
Jeričević, Ž. (2016). 'Non-linear Optimization of Parameters in Hill Kinetics', Croatica Chemica Acta, 89(2), str. 213-215. https://doi.org/10.5562/cca2863
Vancouver
Jeričević Ž. Non-linear Optimization of Parameters in Hill Kinetics. Croatica Chemica Acta [Internet]. 2016 [pristupljeno 07.03.2021.];89(2):213-215. https://doi.org/10.5562/cca2863
IEEE
Ž. Jeričević, "Non-linear Optimization of Parameters in Hill Kinetics", Croatica Chemica Acta, vol.89, br. 2, str. 213-215, 2016. [Online]. https://doi.org/10.5562/cca2863

Sažetak
A novel least squares optimization of parameters in Hill enzyme kinetics has been developed. The method is based on transformation into “Michaelis-Menten like” type of equation with guaranteed convergence and the initial guess equal to zero. By using this approach, a three parameters non-linear optimization problem is transformed into a one-dimensional search for Hill’s coefficient (exponential parameter n).
Numerical experiments illustrating feasibility of the method and quality of the solution are presented.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
Hill; enzyme kinetics; non-linear; optimization; data processing; least squares

Hrčak ID: 168222

URI
https://hrcak.srce.hr/168222

Posjeta: 1.888 *