Skoči na glavni sadržaj

Croatian Medical Journal, Vol. 57 No. 1, 2016.

Izvorni znanstveni članak

https://doi.org/10.3325/cmj.2016.57.6

Which questionnaires should we use to evaluate quality of life in patients with chronic graft-vs-host disease?

Zinaida Perić ; Department of Internal Medicine University of Zagreb, School of Medicine, Zagreb, Croatia
Lana Desnica ; Department of Internal Medicine, Division of Hematology, University Hospital Centre Zagreb, Zagreb,
Nadira Duraković ; Department of Internal Medicine, Division of Hematology, University Hospital Centre Zagreb, Zagreb,
Alen Ostojić ; Department of Internal Medicine, Division of Hematology, University Hospital Centre Zagreb, Zagreb,
Dražen Pulanić ; Department of Internal Medicine University of Zagreb, School of Medicine, Zagreb, Croatia
Ranka Serventi-Seiwerth ; Department of Internal Medicine, Division of Hematology, University Hospital Centre Zagreb, Zagreb,
Ema Prenc ; Croatian Cooperative Group for Hematologic Diseases, Zagreb, Croatia
Grzegorz Basak ; Department of Hematology Oncology and Internal Diseases Medical University of WarsawWarsaw, Poland
Radovan Vrhovac ; Department of Internal Medicine University of Zagreb, School of Medicine, Zagreb, Croatia
Steven Z Pavletic ; National Cancer Institute, Bethesda, MD, USA
Damir Nemet ; Department of Internal Medicine University of Zagreb, School of Medicine, Zagreb, Croatia

Puni tekst: engleski pdf 225 Kb

str. 6-15

preuzimanja: 438

citiraj

Sažetak

Aim To investigate the ability of two standard quality of life
(QOL) questionnaires – The Short Form (36-item) Health
Survey (SF-36) and The European Organisation for Research
and Treatment of Cancer Quality of Life Questionnaire-
Core 30 (EORTC QLQ C30) to evaluate QOL in patients with
chronic graft-vs-host disease (cGVHD) graded according to
National Institutes of Health (NIH) consensus criteria.
Methods In this cross-sectional study, QOL was assessed
in patients who underwent allogeneic stem cell transplantation
(allo-SCT) at the University Hospital Centre Zagreb
and were alive and in complete remission for more than
one year after allo-SCT.
Results The study included 58 patients, 38 patients with
cGVHD and 20 controls, patients without cGVHD. Patients
with cGVHD scored according to the NIH criteria had significantly
lower scores of global health status and lower
QOL on all SF-36 subscales and most of QLQ C30 functional
subscales (P < 0.050 for all comparisons). Furthermore,
patients with active cGVHD had significantly lower QOL
scores than patients with inactive cGVHD, and this difference
was most evident in physical functioning subscale of
SF-36 (P = 0.0007) and social functioning subscale of QLQ
C30 (P = 0.009).
Conclusion cGVHD scored according to the NIH criteria
is correlated with patient-reported QOL, particularly in the
physical domains as detected by SF-36. QLQ C30 questionnaire
adds more information on social functioning and
should be used as a valuable tool in the evaluation of social
domains in cGVHD patients.

Ključne riječi

Hrčak ID:

169149

URI

https://hrcak.srce.hr/169149

Datum izdavanja:

15.2.2016.

Posjeta: 924 *