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https://doi.org/10.3325/cmj.2016.57.16

The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation

Diana Ditz ; Department of Internal Medicine III, University of Regensburg Medical Center, Regensburg,Germany
Robert Rabanus ; Department of Internal Medicine III, University of Regensburg Medical Center, Regensburg,Germany
Christian Schulz ; Department of Internal Medicine Center, Regensburg, Germany
Daniel Wolff ; Department of Internal Medicine III, University of Regensburg Medical Center, Regensburg,Germany
Barbara Holler ; Department of Internal Medicine III, University of Regensburg Medical Center, Regensburg,Germany
Ernst Holler ; Department of Internal Medicine III, University of Regensburg Medical Center, Regensburg,Germany
Gerhard Carl Hildebrandt ; Division of Hematology and Blood and Marrow Transplantation, Markey Cancer Center, University of Kentucky, Lexington, KY, USA

Puni tekst: engleski, pdf (778 KB) str. 16-28 preuzimanja: 351* citiraj
APA 6th Edition
Ditz, D., Rabanus, R., Schulz, C., Wolff, D., Holler, B., Holler, E. i Hildebrandt, G.C. (2016). The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation. Croatian Medical Journal, 57 (1), 16-28. https://doi.org/10.3325/cmj.2016.57.16
MLA 8th Edition
Ditz, Diana, et al. "The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation." Croatian Medical Journal, vol. 57, br. 1, 2016, str. 16-28. https://doi.org/10.3325/cmj.2016.57.16. Citirano 10.05.2021.
Chicago 17th Edition
Ditz, Diana, Robert Rabanus, Christian Schulz, Daniel Wolff, Barbara Holler, Ernst Holler i Gerhard Carl Hildebrandt. "The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation." Croatian Medical Journal 57, br. 1 (2016): 16-28. https://doi.org/10.3325/cmj.2016.57.16
Harvard
Ditz, D., et al. (2016). 'The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation', Croatian Medical Journal, 57(1), str. 16-28. https://doi.org/10.3325/cmj.2016.57.16
Vancouver
Ditz D, Rabanus R, Schulz C, Wolff D, Holler B, Holler E i sur. The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation. Croat Med J. [Internet]. 2016 [pristupljeno 10.05.2021.];57(1):16-28. https://doi.org/10.3325/cmj.2016.57.16
IEEE
D. Ditz, et al., "The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation", Croatian Medical Journal, vol.57, br. 1, str. 16-28, 2016. [Online]. https://doi.org/10.3325/cmj.2016.57.16

Sažetak
Aim To retrospectively assess if the modified lung function
score (LFS) and/or its components, forced expiratory volume
within the first second (FEV1) and diffusion capacity
for carbon monoxide corrected for hemoglobin level (cDLCO),
predict overall survival (OS) and chronic graft-vs-hostdisease
(cGvHD).
Methods We evaluated 241 patients receiving allogeneic
hematopoietic stem cell transplantation (allo-HSCT) at the
University of Regensburg Transplant Center between June
1998 and July 2005 in relation to their LFS, FEV1 and cDLCO,
before and after HSCT.
Results Decreased OS after allo-HSCT was related to decreased
pre-transplantation values of FEV1<60% (P = 0.040),
cDLCO<50% of predicted value (P = 0.025), and LFS≥III
(P = 0.037). It was also related to decreased FEV1 at 3 and 12
months after HSCT (P < 0.001 and P = 0.001, respectively)
and increased LFS at 3 and 12 months after HSCT (P = 0.028
and P = 0.002, respectively), but not to changes of cDLCO. A
higher incidence of cGvHD was related to decreased FEV1
at 6, 12, and 18 months (P = 0.069, P = 0.054, and P = 0.009,
respectively) and increased LFS at 12 months (P = 0.002),
but not to changes in cDLCO.
Conclusions OS was related to both LFS and FEV1, but
cGvHD had a stronger relation to FEV1 than to cDLCO or
LFS. FEV1 alone offered more information on the outcome
after allo-HSCT than LFS or cDLCO, suggesting limited value
of LFS for the patients’ assessment after allo-HSCT.

Hrčak ID: 169150

URI
https://hrcak.srce.hr/169150

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