Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2016.57.16
The lung function score and its components as predictors of overall survival and chronic graft-vs-host disease after allogeneic stem cell transplantation
Diana Ditz
; Department of Internal Medicine III, University of Regensburg Medical Center, Regensburg,Germany
Robert Rabanus
; Department of Internal Medicine III, University of Regensburg Medical Center, Regensburg,Germany
Christian Schulz
; Department of Internal Medicine Center, Regensburg, Germany
Daniel Wolff
; Department of Internal Medicine III, University of Regensburg Medical Center, Regensburg,Germany
Barbara Holler
; Department of Internal Medicine III, University of Regensburg Medical Center, Regensburg,Germany
Ernst Holler
; Department of Internal Medicine III, University of Regensburg Medical Center, Regensburg,Germany
Gerhard Carl Hildebrandt
; Division of Hematology and Blood and Marrow Transplantation, Markey Cancer Center, University of Kentucky, Lexington, KY, USA
Sažetak
Aim To retrospectively assess if the modified lung function
score (LFS) and/or its components, forced expiratory volume
within the first second (FEV1) and diffusion capacity
for carbon monoxide corrected for hemoglobin level (cDLCO),
predict overall survival (OS) and chronic graft-vs-hostdisease
(cGvHD).
Methods We evaluated 241 patients receiving allogeneic
hematopoietic stem cell transplantation (allo-HSCT) at the
University of Regensburg Transplant Center between June
1998 and July 2005 in relation to their LFS, FEV1 and cDLCO,
before and after HSCT.
Results Decreased OS after allo-HSCT was related to decreased
pre-transplantation values of FEV1<60% (P = 0.040),
cDLCO<50% of predicted value (P = 0.025), and LFS≥III
(P = 0.037). It was also related to decreased FEV1 at 3 and 12
months after HSCT (P < 0.001 and P = 0.001, respectively)
and increased LFS at 3 and 12 months after HSCT (P = 0.028
and P = 0.002, respectively), but not to changes of cDLCO. A
higher incidence of cGvHD was related to decreased FEV1
at 6, 12, and 18 months (P = 0.069, P = 0.054, and P = 0.009,
respectively) and increased LFS at 12 months (P = 0.002),
but not to changes in cDLCO.
Conclusions OS was related to both LFS and FEV1, but
cGvHD had a stronger relation to FEV1 than to cDLCO or
LFS. FEV1 alone offered more information on the outcome
after allo-HSCT than LFS or cDLCO, suggesting limited value
of LFS for the patients’ assessment after allo-HSCT.
Ključne riječi
Hrčak ID:
169150
URI
Datum izdavanja:
15.2.2016.
Posjeta: 1.193 *