Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2016.57.255
Adiponectin and resistin in acute and chronic graft-vs-host disease patients undergoing allogeneic hematopoietic stem cell transplantation
Oliver Robak
; Department of Medicine I, Medical University of Vienna, Vienna, Austria
Zoya Kuzmina
; Department of Medicine I, Medical University of Vienna, Vienna, Austria
Andreas Winkler
; Department of Medicine I, Medical University of Vienna, Vienna, Austria
Peter Kalhs
; Department of Medicine I, Medical University of Vienna, Vienna, Austria
Werner Rabitsch
; Department of Medicine I, Medical University of Vienna, Vienna, Austria
Hildegard Greinix
; Department of Medicine I, Medical University of Vienna, Vienna, Austria
Sažetak
Aim To investigate the association of adiponectin and resistin
levels in patients undergoing hematopoietic stem
cell transplantation (HSCT) with the clinical outcome, including
the occurrence of acute and chronic graft-vs-host
disease (GVHD), non-relapse mortality, and overall survival.
Methods We prospectively collected serum samples
from 40 patients undergoing either autologous (n = 12;
10 male) or allogeneic (n = 28; 11 male) HSCT for up to 12
months post HSCT and determined adiponectin and resistin
serum concentrations using enzyme-linked immunosorbent
assay.
Results There were no significant differences in adiponectin
levels (18.5 vs 9.3 μg/mL, P = 0.071) and adiponectin/
BMI ratio (0.82 vs 0.39, P = 0.068) between patients with
acute GVHD grades 2-4 and autologous controls. However,
resistin values were significantly lower in patients with
acute GVHD grades 2-4 than in autologous controls (4.6
vs 7.3 ng/mL, P = 0.030). Adiponectin levels were higher
in patients with chronic GVHD (n = 17) than in autologous
controls (13.5 vs 7.6 μg/mL, P = 0.051), but the difference
was not significant. Adiponectin/BMI ratio was significantly
higher in patients with chronic GVHD than in autologous
controls (0.59 vs 0.25, P = 0.006). Patients dying from relapse
also had significantly lower adiponectin levels (8.2 μg/mL)
and adiponectin/BMI ratio (0.3) on admission than surviving
allogeneic (15.8 μg/mL, P = 0.030 and 0.7, P = 0.004) and
surviving autologous patients (19.2 μg/mL, P = 0.031 and
0.7, P = 0.021).
Conclusion Adiponectin and resistin levels were altered in
patients with acute and chronic GVHD compared to autologous
controls and were associated with overall survival and
relapse mortality in patients undergoing allogeneic HSCT.
Ključne riječi
Hrčak ID:
169616
URI
Datum izdavanja:
15.6.2016.
Posjeta: 897 *