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Arhiv za higijenu rada i toksikologiju, Vol. 58 No. 3, 2007.

Izvorni znanstveni članak
https://doi.org/10.2478/v10004-007-0019-1

Changes in Liver and Brain Cytochrome P450 After Multiple Cocaine Administration, Alone and in Combination With Nifedipine

Vessela Vitcheva
Mitka Mitcheva

Puni tekst: engleski, pdf (68 KB) str. 287-291 preuzimanja: 946* citiraj
APA 6th Edition
Vitcheva, V. i Mitcheva, M. (2007). Changes in Liver and Brain Cytochrome P450 After Multiple Cocaine Administration, Alone and in Combination With Nifedipine. Arhiv za higijenu rada i toksikologiju, 58 (3), 287-291. https://doi.org/10.2478/v10004-007-0019-1
MLA 8th Edition
Vitcheva, Vessela i Mitka Mitcheva. "Changes in Liver and Brain Cytochrome P450 After Multiple Cocaine Administration, Alone and in Combination With Nifedipine." Arhiv za higijenu rada i toksikologiju, vol. 58, br. 3, 2007, str. 287-291. https://doi.org/10.2478/v10004-007-0019-1. Citirano 20.02.2019.
Chicago 17th Edition
Vitcheva, Vessela i Mitka Mitcheva. "Changes in Liver and Brain Cytochrome P450 After Multiple Cocaine Administration, Alone and in Combination With Nifedipine." Arhiv za higijenu rada i toksikologiju 58, br. 3 (2007): 287-291. https://doi.org/10.2478/v10004-007-0019-1
Harvard
Vitcheva, V., i Mitcheva, M. (2007). 'Changes in Liver and Brain Cytochrome P450 After Multiple Cocaine Administration, Alone and in Combination With Nifedipine', Arhiv za higijenu rada i toksikologiju, 58(3), str. 287-291. doi: https://doi.org/10.2478/v10004-007-0019-1
Vancouver
Vitcheva V, Mitcheva M. Changes in Liver and Brain Cytochrome P450 After Multiple Cocaine Administration, Alone and in Combination With Nifedipine. Arh Hig Rada Toksikol. [Internet]. 2007 [pristupljeno 20.02.2019.];58(3):287-291. doi: https://doi.org/10.2478/v10004-007-0019-1
IEEE
V. Vitcheva i M. Mitcheva, "Changes in Liver and Brain Cytochrome P450 After Multiple Cocaine Administration, Alone and in Combination With Nifedipine", Arhiv za higijenu rada i toksikologiju, vol.58, br. 3, str. 287-291, 2007. [Online]. doi: https://doi.org/10.2478/v10004-007-0019-1

Sažetak
The objective of this study was to evaluate possible changes caused by multiple cocaine administration, alone and in combination with 1,4-dihydropiridine calcium channel blocker nifedipine, on cytochrome P450 levels both in the brain and liver. The experiment was done on male Wistar rats divided in four groups: control, treated with nifedipine (5 mg kg-1 i.p. for five days), treated with cocaine (15 mg kg-1 i.p. for five days), and treated with nifedipine and 30 minutes later with cocaine (also for five days). Total cytochrome P450 was measured spectrometrically in liver and brain microsomes. Multiple administration of cocaine alone and in combination with nifedipine did not change the brain P450 significantly. In the liver, nifedipine significantly increased P450 by 28 % vs. control. In contrast, cocaine significantly decreased P450 by 17 % vs. control. In animals treated with nifedipine and cocaine, cytochrome P450 increased 11 % (p<0.01) vs. control, decreased 12.5 % (p<0.001) vs. nifedipine group and increased 34 % (p<0.0001) vs. cocaine group. These results suggest that the cocaine and nifedipine interact at the metabolic level.

Ključne riječi
calcium channel blocker; metabolism; microsomes; in vivo interactions

Hrčak ID: 16523

URI
https://hrcak.srce.hr/16523

[hrvatski]

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