hrcak mascot   Srce   HID

Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2016.57.321

Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review

Andrea Gelemanović ; School of Medicine, University of Split, Split, Croatia
Katie Dobberpuhl ; Medical student, Medical College of Wisconsin, Milwaukee, WI, USA
Goran Krakar ; Children’s Hospital Zagreb, Zagreb, Croatia
Inga Patarčić ; School of Medicine, University of Split, Split, Croatia
Ivana Kolčić   ORCID icon orcid.org/0000-0001-7918-6052 ; School of Medicine, University of Split, Split, Croatia
Ozren Polašek   ORCID icon orcid.org/0000-0002-5765-1862 ; School of Medicine, University of Split, Split, Croatia

Puni tekst: engleski, pdf (683 KB) str. 321-330 preuzimanja: 192* citiraj
APA 6th Edition
Gelemanović, A., Dobberpuhl, K., Krakar, G., Patarčić, I., Kolčić, I. i Polašek, O. (2016). Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review. Croatian medical journal, 57 (4), 321-330. https://doi.org/10.3325/cmj.2016.57.321
MLA 8th Edition
Gelemanović, Andrea, et al. "Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review." Croatian medical journal, vol. 57, br. 4, 2016, str. 321-330. https://doi.org/10.3325/cmj.2016.57.321. Citirano 20.11.2019.
Chicago 17th Edition
Gelemanović, Andrea, Katie Dobberpuhl, Goran Krakar, Inga Patarčić, Ivana Kolčić i Ozren Polašek. "Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review." Croatian medical journal 57, br. 4 (2016): 321-330. https://doi.org/10.3325/cmj.2016.57.321
Harvard
Gelemanović, A., et al. (2016). 'Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review', Croatian medical journal, 57(4), str. 321-330. https://doi.org/10.3325/cmj.2016.57.321
Vancouver
Gelemanović A, Dobberpuhl K, Krakar G, Patarčić I, Kolčić I, Polašek O. Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review. Croat Med J. [Internet]. 2016 [pristupljeno 20.11.2019.];57(4):321-330. https://doi.org/10.3325/cmj.2016.57.321
IEEE
A. Gelemanović, K. Dobberpuhl, G. Krakar, I. Patarčić, I. Kolčić i O. Polašek, "Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review", Croatian medical journal, vol.57, br. 4, str. 321-330, 2016. [Online]. https://doi.org/10.3325/cmj.2016.57.321

Sažetak
Aim To summarize available evidence on the role of host
genetics in the susceptibility to congenital and childhood
cytomegalovirus (CMV) infections by conducting a systematic
review of published studies.
Methods We searched online databases (PubMed, Web of
Science, Scopus and HuGe Navigator) for relevant studies
with well-defined inclusion and exclusion criteria and assessed
the risk of bias using novel Confounding-Selection-
Information bias score (CSI).
Results 5105 studies were initially identified, but only 5
met all the inclusion criteria and were analyzed in detail.
Polymorphisms of the toll-like receptors (TLRs) and mannose-
binding lectin (MBL) genes were shown to have an
impact on the CMV infection in infants. Polymorphisms
of the TLR2 (rs3804100, rs1898830), TLR4 (rs4986791), and
TLR9 (rs352140) were shown to have a role in congenital
CMV infection. Low MBL levels were associated with CMV
infection in Chinese individuals, a finding that was not replicated
in Caucasians. The overall credibility of evidence
was weak.
Conclusions Based on currently available very limited
amount of evidence, it is uncertain whether congenital
and childhood CMV infections are under host genetic control.
Additional primary studies are needed with more specific
research hypotheses that will enable gradual understanding
of specific mechanisms of the CMV pathogenesis.
More genetic studies in the future will facilitate better understanding
of host susceptibility and likely enable novel
preventative and curative measures

Projekti
EC / FP7 / 602525 / PREPARE - Platform foR European Preparedness Against (Re-)emerging Epidemics

Hrčak ID: 170174

URI
https://hrcak.srce.hr/170174

Posjeta: 281 *