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https://doi.org/10.3325/cmj.2016.57.434

Higher glucose level and systemic oxidative stress decrease the mean velocity index of the retinal artery during flickering light stimulation in type 1 diabetes

Vladimir Debelić ; University Eye Clinic, University University Medical Center in Ljubljana Ljubljana, Slovenia
Brigita Drnovšek Olup ; University Eye Clinic, University University Medical Center in Ljubljana Ljubljana, Slovenia
Bogomir Žižek ; Faculty of Health Sciences, University of Ljubljana, Ljubljana Slovenia
Milan Skitek ; Institute for Clinical Chemistry and Biochemistry, University MedicalCentre in Ljubljana, LjubljanaSlovenia
Aleš Jerin ; Institute for Clinical Chemistry and Biochemistry, University MedicalCentre in Ljubljana, LjubljanaSlovenia


Puni tekst: engleski pdf 448 Kb

str. 434-441

preuzimanja: 441

citiraj


Sažetak

Aim To determine whether higher glucose level and systemic
oxidative stress decrease mean velocity (MV) index
of the central retinal artery (CRA) during flickering light
stimulation in type 1 diabetes (T1D).
Methods The study was performed in the period from
2008 to 2015 at the University Eye Clinic in Ljubljana. 41 patients
with T1D and 37 participants without diabetes were
included. MV in the CRA was measured using Doppler ultrasound
diagnostics in basal conditions and during 8 Hz
flickering light irritation. The plasma levels of glucose, fructosamine,
8-hydroxy-2’-deoxyguanosine (8-OHdG), triglycerides,
cholesterol, and low-density lipoprotein (LDL) were
measured.
Results Patients with T1D had significantly higher levels
of blood glucose (P < 0.001), fructosamine (P < 0.001), and
8-OHdG (P < 0.001), but there were no significant differences
in triglycerides (P = 0.108), cholesterol (P = 0.531), and LDL
(P = 0.645) between the groups. Patients with T1D also
had a significantly lower MV index in the CRA (1.11 ± 0.15
vs 1.24 ± 0.23; P = 0.010). In the T1D group, a significant
negative correlation was found between the level of
glucose (r = −0.58; P < 0.001), fructosamine (r = −0.46;
P = 0.003), 8-OHdG (r = −0.48; P = 0.002) and the MV index
in the CRA. At the same time, in this group fructosamine
and 8-OHdG levels had a separate effect on the MV index
(adjusted R2 = 0.38, P < 0.001).
Conclusion Higher glucose levels, the medium-term glucose
level, and systemic oxidative stress could importantly
reduce retinal vasodilatation during flickering light irritation
in patients with T1D

Ključne riječi

Hrčak ID:

170456

URI

https://hrcak.srce.hr/170456

Datum izdavanja:

15.10.2016.

Posjeta: 827 *