hrcak mascot   Srce   HID

Izvorni znanstveni članak
https://doi.org/10.1515/aiht-2016-67-2795

Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats

Milica G. Paunović ; Faculty of Science, University of Kragujevac, Kragujevac, Serbia
Branka I. Ognjanović ; Faculty of Science, University of Kragujevac, Kragujevac, Serbia
Miloš M. Matić ; Faculty of Science, University of Kragujevac, Kragujevac, Serbia
Andraš Š. Štajn ; Faculty of Science, University of Kragujevac, Kragujevac, Serbia
Zorica S. Saičić ; Department of Physiology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia

Puni tekst: engleski, pdf (584 KB) str. 304-309 preuzimanja: 665* citiraj
APA 6th Edition
Paunović, M.G., Ognjanović, B.I., Matić, M.M., Štajn, A.Š. i Saičić, Z.S. (2016). Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats. Arhiv za higijenu rada i toksikologiju, 67 (4), 304-309. https://doi.org/10.1515/aiht-2016-67-2795
MLA 8th Edition
Paunović, Milica G., et al. "Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats." Arhiv za higijenu rada i toksikologiju, vol. 67, br. 4, 2016, str. 304-309. https://doi.org/10.1515/aiht-2016-67-2795. Citirano 05.03.2021.
Chicago 17th Edition
Paunović, Milica G., Branka I. Ognjanović, Miloš M. Matić, Andraš Š. Štajn i Zorica S. Saičić. "Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats." Arhiv za higijenu rada i toksikologiju 67, br. 4 (2016): 304-309. https://doi.org/10.1515/aiht-2016-67-2795
Harvard
Paunović, M.G., et al. (2016). 'Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats', Arhiv za higijenu rada i toksikologiju, 67(4), str. 304-309. https://doi.org/10.1515/aiht-2016-67-2795
Vancouver
Paunović MG, Ognjanović BI, Matić MM, Štajn AŠ, Saičić ZS. Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats. Arh Hig Rada Toksikol. [Internet]. 2016 [pristupljeno 05.03.2021.];67(4):304-309. https://doi.org/10.1515/aiht-2016-67-2795
IEEE
M.G. Paunović, B.I. Ognjanović, M.M. Matić, A.Š. Štajn i Z.S. Saičić, "Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats", Arhiv za higijenu rada i toksikologiju, vol.67, br. 4, str. 304-309, 2016. [Online]. https://doi.org/10.1515/aiht-2016-67-2795

Sažetak
Nicotine is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. The aim of our study was to investigate the prooxidative effects of nicotine and protective (additive or synergistic) effects of quercetin and vitamin C in the blood of experimental animals, to determine whether the combination of these antioxidants might be beneficial for clinical purposes. Wistar albino rats were receiving intraperitoneal nicotine injection (0.75 mg kg-1 per day) or saline (control group) or nicotine plus quercetin (40 mg kg-1 per day) and vitamin C (100 mg kg-1 per day) for three consecutive days. On day 4, we determined their blood lipid profile, liver enzymes, oxidative stress parameters, and antioxidative system parameters. Compared to untreated control, nicotine significantly increased total cholesterol, LDL-cholesterol, triglycerides, liver enzymes (alanine transaminase, aspartate transaminase, and lactate dehydrogenase) and oxidative stress parameters (superoxide anion, hydrogen peroxide, and lipid peroxide) and decreased HDL-cholesterol, glutathione, and superoxide dismutase/catalase activity. Quercetin + vitamin C reversed these values significantly compared to the nicotine alone group. Our results confirm that nicotine has significant prooxidative effects that may disrupt the redox balance and show that the quercetin + vitamin C combination supports antioxidant defence mechanisms with strong haematoprotective activity against nicotine-induced toxicity. In practical terms, this means that a diet rich in vitamin C and quercetin could prevent nicotine-induced toxicity and could also be useful in the supportive care of people exposed to nicotine.

Ključne riječi
antioxidant defence; erythrocytes; lipid profile; oxidative damage; reactive oxygen species; tobacco

Hrčak ID: 170512

URI
https://hrcak.srce.hr/170512

[hrvatski]

Posjeta: 905 *