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SUGAMMADEX, A NEW DRUG FOR REVERSION OF MUSCLE RELAXANTS

Slavica Kvolik
Višnja Ikić
Marko Jukić

Fulltext: croatian, pdf (289 KB) pages 0-0 downloads: 84* cite
APA 6th Edition
Kvolik, S., Ikić, V. & Jukić, M. (2011). SUGAMADEKS, NOVI ANTAGONIST MIŠIĆNIH RELAKSATORA. Liječnički vjesnik, 133 (3-4), 0-0. Retrieved from https://hrcak.srce.hr/171665
MLA 8th Edition
Kvolik, Slavica, et al. "SUGAMADEKS, NOVI ANTAGONIST MIŠIĆNIH RELAKSATORA." Liječnički vjesnik, vol. 133, no. 3-4, 2011, pp. 0-0. https://hrcak.srce.hr/171665. Accessed 21 Nov. 2019.
Chicago 17th Edition
Kvolik, Slavica, Višnja Ikić and Marko Jukić. "SUGAMADEKS, NOVI ANTAGONIST MIŠIĆNIH RELAKSATORA." Liječnički vjesnik 133, no. 3-4 (2011): 0-0. https://hrcak.srce.hr/171665
Harvard
Kvolik, S., Ikić, V., and Jukić, M. (2011). 'SUGAMADEKS, NOVI ANTAGONIST MIŠIĆNIH RELAKSATORA', Liječnički vjesnik, 133(3-4), pp. 0-0. Available at: https://hrcak.srce.hr/171665 (Accessed 21 November 2019)
Vancouver
Kvolik S, Ikić V, Jukić M. SUGAMADEKS, NOVI ANTAGONIST MIŠIĆNIH RELAKSATORA. Liječnički vjesnik [Internet]. 2011 [cited 2019 November 21];133(3-4):0-0. Available from: https://hrcak.srce.hr/171665
IEEE
S. Kvolik, V. Ikić and M. Jukić, "SUGAMADEKS, NOVI ANTAGONIST MIŠIĆNIH RELAKSATORA", Liječnički vjesnik, vol.133, no. 3-4, pp. 0-0, 2011. [Online]. Available: https://hrcak.srce.hr/171665. [Accessed: 21 November 2019]

Abstracts
Sugammadex is a new pharmacological agent for neuromuscular block reversion. It is a cyclic oligosaccharide, a gamma cyclodextrin with lipophylic inner coat that enables forming of stable complexes with steroidal neuromuscular blocking drugs, especially with rocuronium. A physical encapsulation of the relaxants is a novel elimination pathway and it produces fast and complete reversion of both deep and shallow neuromuscular block. Consequently, sugammadex has no unwanted cholinergic muscarinic effects observed with cholinesterase inhibitors such as bradycardia, hypersalivation, and increased gastrointestinal motility. Since the effects of sugammadex are dose dependent it can very rapidly reverse the effects of rocuronium. After the adjusted dose of sugammadex was given, the duration of action of rocuronium can be made as short as that of succinylcholine. This characteristic is especially important in the ’can’t intubate, can’t ventilate’ situation and after surgical procedure was unexpectedly finished. Clinical studies involving more patients are needed to show the real risk-benefit profile and safety in the special patients’ populations

Keywords
Gamma-cyclodextrins – pharmacology, administration and dosage, adverse effects; Neuromuscular nondepolarizing agents – administration and dosage, antagonists and inhibitors; Androstanols – administration and dosage, antagonists and inhibitors; Vecuronium bromide – administration and dosage, antagonists and inhibitors; Neuromuscular blockade – methods

Hrčak ID: 171665

URI
https://hrcak.srce.hr/171665

[croatian]

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