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MESENCHYMAL STEM CELLS: IMMUNOMODULATORY PROPERTIES AND CLINICAL APPLICATION

Mirna Golemović
Marijana Škifić
Branka Golubić Ćepulić

Puni tekst: hrvatski, pdf (539 KB) str. 0-0 preuzimanja: 71* citiraj
APA 6th Edition
Golemović, M., Škifić, M. i Golubić Ćepulić, B. (2012). MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA. Liječnički vjesnik, 134 (1-2), 0-0. Preuzeto s https://hrcak.srce.hr/172395
MLA 8th Edition
Golemović, Mirna, et al. "MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA." Liječnički vjesnik, vol. 134, br. 1-2, 2012, str. 0-0. https://hrcak.srce.hr/172395. Citirano 17.10.2019.
Chicago 17th Edition
Golemović, Mirna, Marijana Škifić i Branka Golubić Ćepulić. "MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA." Liječnički vjesnik 134, br. 1-2 (2012): 0-0. https://hrcak.srce.hr/172395
Harvard
Golemović, M., Škifić, M., i Golubić Ćepulić, B. (2012). 'MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA', Liječnički vjesnik, 134(1-2), str. 0-0. Preuzeto s: https://hrcak.srce.hr/172395 (Datum pristupa: 17.10.2019.)
Vancouver
Golemović M, Škifić M, Golubić Ćepulić B. MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA. Liječnički vjesnik [Internet]. 2012 [pristupljeno 17.10.2019.];134(1-2):0-0. Dostupno na: https://hrcak.srce.hr/172395
IEEE
M. Golemović, M. Škifić i B. Golubić Ćepulić, "MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA", Liječnički vjesnik, vol.134, br. 1-2, str. 0-0, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/172395. [Citirano: 17.10.2019.]

Sažetak
Mesenchymal stem cells (MSCs) are multipotent nonhematopoietic cells that were first identified in bone marrow. Clinical interest for MSCs was initiated by the observation that MSCs are immunoprivileged cells that display immunomodulatory properties in vitro. Ex vivo expanded MSCs have therefore become a new type of cellular therapy in development with a wide range of potential clinical applications. So far many clinical studies confirmed safety of their use and showed that infused MSCs suppress graft versus host disease, support engraftment of transplanted allogeneic hematopoietic stem cells and stimulate growth in patients with osteogenesis imperfecta. Although underlying immunomodulatory mechanisms of action are not completely understood, potential benefit of MSC therapy justifies its clinical use in a broad range of disorders. In this report we give historical overview of MSC discovery and current scientific and clinical achievements in this field. Better insight into their biological properties and mechanisms of action are needed.

Ključne riječi
Mesenchymal stem cells – immunology; Multipotent stem cells – immunology; Immunomodulation; Mesenchimal stem cell transplantation

Hrčak ID: 172395

URI
https://hrcak.srce.hr/172395

[hrvatski]

Posjeta: 258 *