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Review article

MESENCHYMAL STEM CELLS: IMMUNOMODULATORY PROPERTIES AND CLINICAL APPLICATION

Mirna Golemović
Marijana Škifić
Branka Golubić Ćepulić

Fulltext: croatian, pdf (539 KB) pages 0-0 downloads: 116* cite
APA 6th Edition
Golemović, M., Škifić, M. & Golubić Ćepulić, B. (2012). MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA. Liječnički vjesnik, 134 (1-2), 0-0. Retrieved from https://hrcak.srce.hr/172395
MLA 8th Edition
Golemović, Mirna, et al. "MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA." Liječnički vjesnik, vol. 134, no. 1-2, 2012, pp. 0-0. https://hrcak.srce.hr/172395. Accessed 23 Nov. 2020.
Chicago 17th Edition
Golemović, Mirna, Marijana Škifić and Branka Golubić Ćepulić. "MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA." Liječnički vjesnik 134, no. 1-2 (2012): 0-0. https://hrcak.srce.hr/172395
Harvard
Golemović, M., Škifić, M., and Golubić Ćepulić, B. (2012). 'MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA', Liječnički vjesnik, 134(1-2), pp. 0-0. Available at: https://hrcak.srce.hr/172395 (Accessed 23 November 2020)
Vancouver
Golemović M, Škifić M, Golubić Ćepulić B. MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA. Liječnički vjesnik [Internet]. 2012 [cited 2020 November 23];134(1-2):0-0. Available from: https://hrcak.srce.hr/172395
IEEE
M. Golemović, M. Škifić and B. Golubić Ćepulić, "MEZENHIMSKE MATIČNE STANICE: IMUNOMODULATORNE ZNAČAJKE I KLINIČKA PRIMJENA", Liječnički vjesnik, vol.134, no. 1-2, pp. 0-0, 2012. [Online]. Available: https://hrcak.srce.hr/172395. [Accessed: 23 November 2020]

Abstracts
Mesenchymal stem cells (MSCs) are multipotent nonhematopoietic cells that were first identified in bone marrow. Clinical interest for MSCs was initiated by the observation that MSCs are immunoprivileged cells that display immunomodulatory properties in vitro. Ex vivo expanded MSCs have therefore become a new type of cellular therapy in development with a wide range of potential clinical applications. So far many clinical studies confirmed safety of their use and showed that infused MSCs suppress graft versus host disease, support engraftment of transplanted allogeneic hematopoietic stem cells and stimulate growth in patients with osteogenesis imperfecta. Although underlying immunomodulatory mechanisms of action are not completely understood, potential benefit of MSC therapy justifies its clinical use in a broad range of disorders. In this report we give historical overview of MSC discovery and current scientific and clinical achievements in this field. Better insight into their biological properties and mechanisms of action are needed.

Keywords
Mesenchymal stem cells – immunology; Multipotent stem cells – immunology; Immunomodulation; Mesenchimal stem cell transplantation

Hrčak ID: 172395

URI
https://hrcak.srce.hr/172395

[croatian]

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