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Review article


Lana Jajac Bručić
Antonio Juretić
Mladen Solarić
Vesna Bišof
Martina Bašić-Koretić
Zoran Rakušić
Fedor Šantek

Fulltext: croatian, pdf (553 KB) pages 0-0 downloads: 646* cite
APA 6th Edition
Jajac Bručić, L., Juretić, A., Solarić, M., Bišof, V., Bašić-Koretić, M., Rakušić, Z. & Šantek, F. (2012). HORMONSKA TERAPIJA RAKA PROSTATE: IMA LI JOŠ DILEMA?. Liječnički vjesnik, 134 (3-4), 0-0. Retrieved from
MLA 8th Edition
Jajac Bručić, Lana, et al. "HORMONSKA TERAPIJA RAKA PROSTATE: IMA LI JOŠ DILEMA?." Liječnički vjesnik, vol. 134, no. 3-4, 2012, pp. 0-0. Accessed 15 Jan. 2021.
Chicago 17th Edition
Jajac Bručić, Lana, Antonio Juretić, Mladen Solarić, Vesna Bišof, Martina Bašić-Koretić, Zoran Rakušić and Fedor Šantek. "HORMONSKA TERAPIJA RAKA PROSTATE: IMA LI JOŠ DILEMA?." Liječnički vjesnik 134, no. 3-4 (2012): 0-0.
Jajac Bručić, L., et al. (2012). 'HORMONSKA TERAPIJA RAKA PROSTATE: IMA LI JOŠ DILEMA?', Liječnički vjesnik, 134(3-4), pp. 0-0. Available at: (Accessed 15 January 2021)
Jajac Bručić L, Juretić A, Solarić M, Bišof V, Bašić-Koretić M, Rakušić Z, et al. HORMONSKA TERAPIJA RAKA PROSTATE: IMA LI JOŠ DILEMA?. Liječnički vjesnik [Internet]. 2012 [cited 2021 January 15];134(3-4):0-0. Available from:
L. Jajac Bručić, et al., "HORMONSKA TERAPIJA RAKA PROSTATE: IMA LI JOŠ DILEMA?", Liječnički vjesnik, vol.134, no. 3-4, pp. 0-0, 2012. [Online]. Available: [Accessed: 15 January 2021]

The strategy for treating prostate cancer patients depends on the assessment of disease extent, assessment of the risk of disease relapse, assessment of life expectancy, comorbidities, affinities and life-style. Since the activity and survival of prostate cancer cells is at least initially dependent on androgen stimulation, hormonal therapy is one of the several standard treatment modalities. Hormonal therapy is aimed at decreasing this androgen stimulation either by lowering androgen production or by blocking receptor binding. Hormonal therapy is in fact androgen-suppressive therapy (AST) or androgen-deprivation therapy (ADT). If effective, it results in the lack of cancer cell stimulation, thus causing their apoptosis and consequently decline in tumor growth and size. Hormonal therapy is used as a first-line treatment modality for metastatic disease. In addition to this indication, hormonal therapy is also used as an adjunct to radiotherapy with curative intent for patients with non-metastic disease but having an intermediate and high risk of disease relapse. In combination with radiotherapy, hormonal therapy can be applied before, concomitantly and after radiotherapy for the duration of 6 months or 2 to 3 years depending on the risk estimation. Regarding hormonal therapy, it can be applied in combination with other treatments, in several ways, and sometimes there might be several options available. This possible lack of a specific recommendation is a consequence of the fact that there is a limited number of adequate clinical studies which, moreover, may have yielded inconsistent results sometimes simply due to the patients’ heterogeneity. Moreover, thanks to the newer and better diagnostic methods enabling the discovery of prostate cancer in earlier disease stages, as well as to the more effective treatments, there is also a prolongation of relapse-free survival and possibly of overall survival in patients having metastic disease. Consequently, the results of earlier clinical studies might no longer be applicable to the new »generations« of upcoming patients. As regards this improved survival, issues of patient’s quality of life and possible side-effects of hormonal therapy are also becoming increasingly relevant because hormonal adverse events are time-dependant and tend to increase in severity with prolongation of hormonal manipulation. Therefore, this paper aims to give an overview of the more recent findings, indications and observations regarding hormonal therapy.

Prostatic neoplasms – drug therapy, radiotherapy; Antineoplastic agents, hormonal – therapeutic use, Androgen antagonists – therapeutic use

Hrčak ID: 172409



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