hrcak mascot   Srce   HID

Izvorni znanstveni članak

COMPARATIVE URINARY BACTERICIDAL ACTIVITY OF ORAL ANTIBIOTICS AGAINST GRAM-POSITIVE PATHOGENS

Branka Bedenić
Ana Budimir
Ana Gverić
Vanda Plečko
Jasmina Vraneš
Marina Bubonja-Šonje
Smilja Kalenić

Puni tekst: hrvatski, pdf (378 KB) str. 0-0 preuzimanja: 48* citiraj
APA 6th Edition
Bedenić, B., Budimir, A., Gverić, A., Plečko, V., Vraneš, J., Bubonja-Šonje, M. i Kalenić, S. (2012). USPOREDNA URINARNA BAKTERICIDNA AKTIVNOST ORALNIH ANTIBIOTIKA PREMA GRAM-POZITIVNIM URINARNIM PATOGENIMA. Liječnički vjesnik, 134 (5-6), 0-0. Preuzeto s https://hrcak.srce.hr/172421
MLA 8th Edition
Bedenić, Branka, et al. "USPOREDNA URINARNA BAKTERICIDNA AKTIVNOST ORALNIH ANTIBIOTIKA PREMA GRAM-POZITIVNIM URINARNIM PATOGENIMA." Liječnički vjesnik, vol. 134, br. 5-6, 2012, str. 0-0. https://hrcak.srce.hr/172421. Citirano 17.10.2019.
Chicago 17th Edition
Bedenić, Branka, Ana Budimir, Ana Gverić, Vanda Plečko, Jasmina Vraneš, Marina Bubonja-Šonje i Smilja Kalenić. "USPOREDNA URINARNA BAKTERICIDNA AKTIVNOST ORALNIH ANTIBIOTIKA PREMA GRAM-POZITIVNIM URINARNIM PATOGENIMA." Liječnički vjesnik 134, br. 5-6 (2012): 0-0. https://hrcak.srce.hr/172421
Harvard
Bedenić, B., et al. (2012). 'USPOREDNA URINARNA BAKTERICIDNA AKTIVNOST ORALNIH ANTIBIOTIKA PREMA GRAM-POZITIVNIM URINARNIM PATOGENIMA', Liječnički vjesnik, 134(5-6), str. 0-0. Preuzeto s: https://hrcak.srce.hr/172421 (Datum pristupa: 17.10.2019.)
Vancouver
Bedenić B, Budimir A, Gverić A, Plečko V, Vraneš J, Bubonja-Šonje M i sur. USPOREDNA URINARNA BAKTERICIDNA AKTIVNOST ORALNIH ANTIBIOTIKA PREMA GRAM-POZITIVNIM URINARNIM PATOGENIMA. Liječnički vjesnik [Internet]. 2012 [pristupljeno 17.10.2019.];134(5-6):0-0. Dostupno na: https://hrcak.srce.hr/172421
IEEE
B. Bedenić, et al., "USPOREDNA URINARNA BAKTERICIDNA AKTIVNOST ORALNIH ANTIBIOTIKA PREMA GRAM-POZITIVNIM URINARNIM PATOGENIMA", Liječnički vjesnik, vol.134, br. 5-6, str. 0-0, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/172421. [Citirano: 17.10.2019.]

Sažetak
In routine bacteriological laboratories the antibacterial activity of antibiotics is determined by in vitro testing, usually by disk-diffusion test. However, in vitro testing does not always reflect antibacterial efficiency of antibiotics in vivo. In this investigation, the urine samples obtained in a single oral dose pharmacokinetic study were examined for their bactericidal activity against a range of relevant Gram-positive urinary tract pathogens. Urinary bactericidal activity of linezolid had been previously compared with ciprofloxacin but not with other oral antibiotics such as b-lactams. Linezolid showed satisfactory urinary bactericidal titres throughout the whole testing period against all Gram-positive cocci. Fluoroquinolones displayed high and persisting levels of urinary bactericidal activity against staphylococci, but their activity against enterococci was weaker. According to the results of ex-vivo testing amoxycillin could be recommended only for infections caused by E. faecalis. Amoxycillin combined with clavulanic acid can be considered as a therapeutic option for infections caused by S. saprophyticus and E. faecalis. Older cephalosporins had high titres only against S. saprophyticus. Their drawback is a short elimination half-time in urine resulting in rapid decrease of urinary bactericidal titers during dosing interval. Furthermore, they do not show activity against enterococci due to their intrinsic resistance to cephalosporins.

Ključne riječi
Gram-positive bacterial infections – microbiology, drug therapy; Urinary tract infections – microbiology, drug therapy; Gram-positive bacteria – drug effects; Anti-bacterial agents – therapeutic use, pharmacology, urine; Ciprofloxacin – therapeutic use, pharmacology, urine; Oxazolidinones – therapeutic use, pharmacology, urine; Administration, oral

Hrčak ID: 172421

URI
https://hrcak.srce.hr/172421

[hrvatski]

Posjeta: 103 *