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CONGENITAL HYPERINSULINISM – NOVEL INSIGHTS INTO ETIOLOGY, DIAGNOSIS AND TREATMENT

Iva Martinac
Marko Bogović
Stipe Batinica
Vladimir Sarnavka
Sanda Huljev Frković
Toni Matić
Jasminka Jakić-Razumović
Otmar Rubin
Tomislav Luetić
Vesna Kušec
Danijela Petković Ramadža
Davor Begović
Vesna Benjak
Andrea Dasović-Buljević
Anko Antabak
Stanko Ćavar
Dijana Kukin
Suzana Sršen-Medančić
Ivo Barić

Puni tekst: hrvatski, pdf (2 MB) str. 0-0 preuzimanja: 182* citiraj
APA 6th Edition
Martinac, I., Bogović, M., Batinica, S., Sarnavka, V., Huljev Frković, S., Matić, T., ... Barić, I. (2012). KONGENITALNI HIPERINZULINIZAM – NOVOSTI O NASTANKU, DIJAGNOSTICIRANJU I LIJEČENJU BOLESTI. Liječnički vjesnik, 134 (9-10), 0-0. Preuzeto s https://hrcak.srce.hr/172446
MLA 8th Edition
Martinac, Iva, et al. "KONGENITALNI HIPERINZULINIZAM – NOVOSTI O NASTANKU, DIJAGNOSTICIRANJU I LIJEČENJU BOLESTI." Liječnički vjesnik, vol. 134, br. 9-10, 2012, str. 0-0. https://hrcak.srce.hr/172446. Citirano 15.10.2019.
Chicago 17th Edition
Martinac, Iva, Marko Bogović, Stipe Batinica, Vladimir Sarnavka, Sanda Huljev Frković, Toni Matić, Jasminka Jakić-Razumović, et al. "KONGENITALNI HIPERINZULINIZAM – NOVOSTI O NASTANKU, DIJAGNOSTICIRANJU I LIJEČENJU BOLESTI." Liječnički vjesnik 134, br. 9-10 (2012): 0-0. https://hrcak.srce.hr/172446
Harvard
Martinac, I., et al. (2012). 'KONGENITALNI HIPERINZULINIZAM – NOVOSTI O NASTANKU, DIJAGNOSTICIRANJU I LIJEČENJU BOLESTI', Liječnički vjesnik, 134(9-10), str. 0-0. Preuzeto s: https://hrcak.srce.hr/172446 (Datum pristupa: 15.10.2019.)
Vancouver
Martinac I, Bogović M, Batinica S, Sarnavka V, Huljev Frković S, Matić T i sur. KONGENITALNI HIPERINZULINIZAM – NOVOSTI O NASTANKU, DIJAGNOSTICIRANJU I LIJEČENJU BOLESTI. Liječnički vjesnik [Internet]. 2012 [pristupljeno 15.10.2019.];134(9-10):0-0. Dostupno na: https://hrcak.srce.hr/172446
IEEE
I. Martinac, et al., "KONGENITALNI HIPERINZULINIZAM – NOVOSTI O NASTANKU, DIJAGNOSTICIRANJU I LIJEČENJU BOLESTI", Liječnički vjesnik, vol.134, br. 9-10, str. 0-0, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/172446. [Citirano: 15.10.2019.]

Sažetak
Congenital hyperinsulinism (CHI) is a major cause of persistent hypoglycemia in the neonatal and early infancy periods. Althought the disease is relatively rare with incidence of about 1: 25 000–50 000 live births, the importance of the disease should not be underestimated. Namely, prompt recognition and management of patients with CHI is essential, if permanent neurological impairment is to be avoided. CHI is caused by mutations in one of the 7 genes involved in the regulation of insulin secretion in pancreatic b-cells. It is important to introduce specific medical therapy as soon as diagnosis is established. Severe, neonatal forms of CHI are often resistant to medications, thus they require surgical procedure. The preoperative genetic testing and scintigraphy are indicated to distinguish histological subtypes of the disease (focal vs. diffuse CHI). Patients with focal disease are usually cured after pancreatic resection, while diffuse disease has much worse prognosis. This manuscript offers novel insights into CHI and emphasizes the role of early diagnosis as crucial for succesful treatment that was recently enriched with novel options.

Ključne riječi
Persistent hyperinsulinemia hypoglycemia of infancy – genetics; diagnosis; pathology; therapy

Hrčak ID: 172446

URI
https://hrcak.srce.hr/172446

[hrvatski]

Posjeta: 432 *