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EXTRACORPOREAL PHOTOPHERESIS IN TREATMENT OF CHRONIC GRAFT VERSUS HOST DISEASE

Ines Bojanić
Ranka Serventi Seiwerth
Sanja Mazić
Klara Dubravčić
Drago Batinić
Branka Golubić Ćepulić
Boris Labar

Puni tekst: hrvatski, pdf (262 KB) str. 0-0 preuzimanja: 93* citiraj
APA 6th Edition
Bojanić, I., Serventi Seiwerth, R., Mazić, S., Dubravčić, K., Batinić, D., Golubić Ćepulić, B. i Labar, B. (2013). EKSTRAKORPORALNA FOTOFEREZA U LIJEČENJU KRONIČNE REAKCIJE TRANSPLANTATA PROTIV PRIMATELJA. Liječnički vjesnik, 135 (5-6), 0-0. Preuzeto s https://hrcak.srce.hr/172475
MLA 8th Edition
Bojanić, Ines, et al. "EKSTRAKORPORALNA FOTOFEREZA U LIJEČENJU KRONIČNE REAKCIJE TRANSPLANTATA PROTIV PRIMATELJA." Liječnički vjesnik, vol. 135, br. 5-6, 2013, str. 0-0. https://hrcak.srce.hr/172475. Citirano 16.10.2019.
Chicago 17th Edition
Bojanić, Ines, Ranka Serventi Seiwerth, Sanja Mazić, Klara Dubravčić, Drago Batinić, Branka Golubić Ćepulić i Boris Labar. "EKSTRAKORPORALNA FOTOFEREZA U LIJEČENJU KRONIČNE REAKCIJE TRANSPLANTATA PROTIV PRIMATELJA." Liječnički vjesnik 135, br. 5-6 (2013): 0-0. https://hrcak.srce.hr/172475
Harvard
Bojanić, I., et al. (2013). 'EKSTRAKORPORALNA FOTOFEREZA U LIJEČENJU KRONIČNE REAKCIJE TRANSPLANTATA PROTIV PRIMATELJA', Liječnički vjesnik, 135(5-6), str. 0-0. Preuzeto s: https://hrcak.srce.hr/172475 (Datum pristupa: 16.10.2019.)
Vancouver
Bojanić I, Serventi Seiwerth R, Mazić S, Dubravčić K, Batinić D, Golubić Ćepulić B i sur. EKSTRAKORPORALNA FOTOFEREZA U LIJEČENJU KRONIČNE REAKCIJE TRANSPLANTATA PROTIV PRIMATELJA. Liječnički vjesnik [Internet]. 2013 [pristupljeno 16.10.2019.];135(5-6):0-0. Dostupno na: https://hrcak.srce.hr/172475
IEEE
I. Bojanić, et al., "EKSTRAKORPORALNA FOTOFEREZA U LIJEČENJU KRONIČNE REAKCIJE TRANSPLANTATA PROTIV PRIMATELJA", Liječnički vjesnik, vol.135, br. 5-6, str. 0-0, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/172475. [Citirano: 16.10.2019.]

Sažetak
Extracorporeal photopheresis (ECP) is an immunomodulatory therapy which has been used in the treatment of chronic GVHD (cGVHD). ECP involves separation of the mononuclear cells with leukapheresis, followed by ex vivo administration of 8-methoxypsoralen and UV-A radiation and reinfusion to the patient. Aim of the study was to evaluate clinical and immunomodulatory effect of ECP procedures in patients with cGVHD. We analyzed 341 ECP procedures performed in 7 patients with cGVHD; median ECP per patient was 37 (range 13–131). All patients suffered from skin changes in combination with impaired joint mobility and symptoms of oral disease. ECP procedures were performed for two consecutive days: in initial phase weekly, followed by every two weeks and than monthly according to clinical response. Median of ECP treatment duration was 10 months (range 2–58). The effect of ECP in patients with cGVHD with skin and joint involvement was mostly beneficial: 6 patients experienced either improvement or stabilization in skin changes and joint mobility. In 2 patients who suffered from oral disease, the total recovery was observed. Clinical response was typically delayed until 2 to 3 months, and reduction in glucocorticoid dose was observed. Adverse reactions were observed in 4.9% procedures. In patients who responded to ECP treatment, CD4+/CD8+ ratio and number of NK cells were normalized. ECP proved to be an efficient and safe procedure that may be recommended for patients with cGVHD who do not respond to conventional therapy

Ključne riječi
Graft vs host disease – diagnosis, therapy; Photopheresis – methods; Hematopoietic stem cell transplantation – adverse effects; Transplantation, homologous; Immunosuppressive agents – therapeutic use; Chronic disease

Hrčak ID: 172475

URI
https://hrcak.srce.hr/172475

[hrvatski]

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