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Professional paper


Dinka Pavičić Baldani
Lana Škrgatić
Velimir Šimunić
Vesna Elveđi Gašparović
Blaž Geršak

Fulltext: croatian, pdf (302 KB) pages 0-0 downloads: 165* cite
APA 6th Edition
Pavičić Baldani, D., Škrgatić, L., Šimunić, V., Elveđi Gašparović, V. & Geršak, B. (2015). HORMONSKO NADOMJESNO LIJEČENJE I VENSKE TROMBOEMBOLIJE. Liječnički vjesnik, 137 (1-2), 0-0. Retrieved from
MLA 8th Edition
Pavičić Baldani, Dinka, et al. "HORMONSKO NADOMJESNO LIJEČENJE I VENSKE TROMBOEMBOLIJE." Liječnički vjesnik, vol. 137, no. 1-2, 2015, pp. 0-0. Accessed 22 Jun. 2021.
Chicago 17th Edition
Pavičić Baldani, Dinka, Lana Škrgatić, Velimir Šimunić, Vesna Elveđi Gašparović and Blaž Geršak. "HORMONSKO NADOMJESNO LIJEČENJE I VENSKE TROMBOEMBOLIJE." Liječnički vjesnik 137, no. 1-2 (2015): 0-0.
Pavičić Baldani, D., et al. (2015). 'HORMONSKO NADOMJESNO LIJEČENJE I VENSKE TROMBOEMBOLIJE', Liječnički vjesnik, 137(1-2), pp. 0-0. Available at: (Accessed 22 June 2021)
Pavičić Baldani D, Škrgatić L, Šimunić V, Elveđi Gašparović V, Geršak B. HORMONSKO NADOMJESNO LIJEČENJE I VENSKE TROMBOEMBOLIJE. Liječnički vjesnik [Internet]. 2015 [cited 2021 June 22];137(1-2):0-0. Available from:
D. Pavičić Baldani, L. Škrgatić, V. Šimunić, V. Elveđi Gašparović and B. Geršak, "HORMONSKO NADOMJESNO LIJEČENJE I VENSKE TROMBOEMBOLIJE", Liječnički vjesnik, vol.137, no. 1-2, pp. 0-0, 2015. [Online]. Available: [Accessed: 22 June 2021]

Venous thromboembolism (VTE) is the most important side effect of using hormone replacement therapy (HRT). Biological and epidemiological studies have shown that oral administration of estrogen is associated with an increased risk of VTE compared to transdermal route of administration. Addition of progestogen to estrogen further increases the risk of VTE. Different pharmacological classes of progestogens differently contribute to the risk of VTE. Observational studies observed that the application of micronized progesterone and didrogesteron are safer regarding the risk of VTE compared to other progestins. These results should be further confirmed in the randomized studies. A personal or family history of VTE, existence of hereditary thrombophilia or/and multiple risk factors for VTE represent a strong contraindication to oral HRT use. In such persons the application of transdermal estrogen can be considered after careful individual evaluation of the benefits and risks. Transdermal estrogen should be also the first choice in overweight/obese women requiring HRT.

Venous thromboembolism – chemically induced; Hormone replacement therapy – adverse effects, methods; Estrogens – therapeutic use, adverse effects, administration and dosage; Administration, oral; Administration, cutaneous; Progestins – therapeutic use, adverse effects; Progesterone – theraputic use; Postmenopause

Hrčak ID: 172679



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