Liječnički vjesnik, Vol. 137 No. 3-4, 2015.
Pregledni rad
ENDEMIC NEPHROPATHY IN CROATIA
Bojan Jelaković
Živka Dika
Sandra Karanović
Ivana Vuković Lela
Sažetak
Endemic nephropathy (EN) is a chronic tubulointerstitial aristolochic acid nephropathy (AAN) affecting residents of the certain villages in the valleys of the major tributaries of the Danube river in the south-east Europe including Croatia. Patients with EN have a significantly higher incidence of transitional cell carcinoma of the ureter than the general population. A-T transversion of the p53 gene is now considered to be a mutational »signature« of aristolochic acid, which is a cause of endemic nephropathy. Currently used diagnostic criteria for EN are outdated, uneven (three types of criteria) and are not in agreement with proposed new guidelines for kidney diseases. Therefore, based on current knowledge and expertise of a group of scientists and experts from all countries with EN as well as world where AAN has been reported, new diagnostic criteria and the new classification of the population of endemic villages were created at a symposium on EN. EN presents a major public health problem and current knowledge about this disease as well as new diagnostic criteria should help us in its early detection and treatment and maybe in a near future its eradication.
Ključne riječi
Balkan nephropathy – epidemiology, etiology, genetics, diagnosis, pathology; Aristolochic acids – toxicity; Carcinogens, environmental – toxicity; Environmental exposure – adverse effects; Ureteral neoplasms – epidemiology, etiology, genetics, diagnosis, pathology; Kidney cortex – pathology; Tumor suppressor protein p53 – genetics; Mutation – genetics; Drugs, chinese herbal – toxicity; Croatia – epidemiology
Hrčak ID:
172692
URI
Datum izdavanja:
5.5.2015.
Posjeta: 2.263 *