hrcak mascot   Srce   HID

Stručni rad

GOODPASTURE’S SYNDROME – CASE REPORTS

Gordana Kotur
Goran Kotur
Ivica Horvatić
Danica Galešić Ljubanović
Krešimir Galešić

Puni tekst: hrvatski, pdf (614 KB) str. 0-0 preuzimanja: 188* citiraj
APA 6th Edition
Kotur, G., Kotur, G., Horvatić, I., Galešić Ljubanović, D. i Galešić, K. (2015). GOODPASTUREOV SINDROM – PRIKAZI BOLESNIKA. Liječnički vjesnik, 137 (5-6), 0-0. Preuzeto s https://hrcak.srce.hr/172704
MLA 8th Edition
Kotur, Gordana, et al. "GOODPASTUREOV SINDROM – PRIKAZI BOLESNIKA." Liječnički vjesnik, vol. 137, br. 5-6, 2015, str. 0-0. https://hrcak.srce.hr/172704. Citirano 24.10.2019.
Chicago 17th Edition
Kotur, Gordana, Goran Kotur, Ivica Horvatić, Danica Galešić Ljubanović i Krešimir Galešić. "GOODPASTUREOV SINDROM – PRIKAZI BOLESNIKA." Liječnički vjesnik 137, br. 5-6 (2015): 0-0. https://hrcak.srce.hr/172704
Harvard
Kotur, G., et al. (2015). 'GOODPASTUREOV SINDROM – PRIKAZI BOLESNIKA', Liječnički vjesnik, 137(5-6), str. 0-0. Preuzeto s: https://hrcak.srce.hr/172704 (Datum pristupa: 24.10.2019.)
Vancouver
Kotur G, Kotur G, Horvatić I, Galešić Ljubanović D, Galešić K. GOODPASTUREOV SINDROM – PRIKAZI BOLESNIKA. Liječnički vjesnik [Internet]. 2015 [pristupljeno 24.10.2019.];137(5-6):0-0. Dostupno na: https://hrcak.srce.hr/172704
IEEE
G. Kotur, G. Kotur, I. Horvatić, D. Galešić Ljubanović i K. Galešić, "GOODPASTUREOV SINDROM – PRIKAZI BOLESNIKA", Liječnički vjesnik, vol.137, br. 5-6, str. 0-0, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/172704. [Citirano: 24.10.2019.]

Sažetak
Goodpasture’s syndrome is a rare clinical entity characterized by rapidly progressive glomerulonephritis, diffuse pulmonary hemorrhage and the presence of circulating autoantibodies to the glomerular basement membrane (GBM). Autoantibodies bind to reactive epitopes of noncollagenous domain of the collagen type IV a-3 chain in glomerular and alveolar basement membranes. Autoantibodies activate the complement cascade resulting in tissue injury by the type II hypersensitivity reaction according to the Coombs and Gell classification of antigen-antibody reactions. Prognostic factors include the renal excretory function and the degree of renal and lung damage at the time of presentation. Prompt diagnosis and early and adequate medical treatment is vital for patients. Clinical treatment must be aggressive in order of achieving better outcome. This article describes three patients who clinically presented with renopulmonary syndrome, renal failure, hematuria, proteinuria and hemoptysis. Kidney biopsy diagnosis was crescentic glomerulonephritis due to antibodies against GBM. In all three patients we started therapy with glucocorticoids and cyclophosphamide combined with plasma exchange therapy. In two patients who initially had severe impairment of renal function and high percentage of crescents in the renal biopsy, kidney function recovery was not achieved. In one patient, who at the time of clinical presentation showed milder renal failure and lower percentage of crescents in renal biopsy, the full recovery of renal function was obtained

Ključne riječi
Anti-glomerular basement membrane disease – diagnosis, immunology, pathology, therapy; Pulmonary alveoli – pathology; Hemoptysis – etiology; Kidney glomerulus – pathology, immunology; Basement membrane – immunology; Autoantibodies – blood; Immunosuppressive agents – therapeutic use; Cyclophosphamide – therapeutic use; Plasmapheresis

Hrčak ID: 172704

URI
https://hrcak.srce.hr/172704

[hrvatski]

Posjeta: 314 *