APA 6th Edition Malčić, I., Grgat, J., Kniewald, H., Šarić, D., Dilber, D. i Bartoniček, D. (2015). BIKUSPIDALNA AORTALNA VALVULA I GRJEŠKE IZLAZNOG TRAKTA LIJEVE KLIJETKE U DJECE – SINDROM BIKUSPIDALNE AORTOPATIJE?. Liječnički vjesnik, 137 (9-10), 0-0. Preuzeto s https://hrcak.srce.hr/172717
MLA 8th Edition Malčić, Ivan, et al. "BIKUSPIDALNA AORTALNA VALVULA I GRJEŠKE IZLAZNOG TRAKTA LIJEVE KLIJETKE U DJECE – SINDROM BIKUSPIDALNE AORTOPATIJE?." Liječnički vjesnik, vol. 137, br. 9-10, 2015, str. 0-0. https://hrcak.srce.hr/172717. Citirano 24.10.2020.
Chicago 17th Edition Malčić, Ivan, Josipa Grgat, Hrvoje Kniewald, Dalibor Šarić, Daniel Dilber i Dorotea Bartoniček. "BIKUSPIDALNA AORTALNA VALVULA I GRJEŠKE IZLAZNOG TRAKTA LIJEVE KLIJETKE U DJECE – SINDROM BIKUSPIDALNE AORTOPATIJE?." Liječnički vjesnik 137, br. 9-10 (2015): 0-0. https://hrcak.srce.hr/172717
Harvard Malčić, I., et al. (2015). 'BIKUSPIDALNA AORTALNA VALVULA I GRJEŠKE IZLAZNOG TRAKTA LIJEVE KLIJETKE U DJECE – SINDROM BIKUSPIDALNE AORTOPATIJE?', Liječnički vjesnik, 137(9-10), str. 0-0. Preuzeto s: https://hrcak.srce.hr/172717 (Datum pristupa: 24.10.2020.)
Vancouver Malčić I, Grgat J, Kniewald H, Šarić D, Dilber D, Bartoniček D. BIKUSPIDALNA AORTALNA VALVULA I GRJEŠKE IZLAZNOG TRAKTA LIJEVE KLIJETKE U DJECE – SINDROM BIKUSPIDALNE AORTOPATIJE?. Liječnički vjesnik [Internet]. 2015 [pristupljeno 24.10.2020.];137(9-10):0-0. Dostupno na: https://hrcak.srce.hr/172717
IEEE I. Malčić, J. Grgat, H. Kniewald, D. Šarić, D. Dilber i D. Bartoniček, "BIKUSPIDALNA AORTALNA VALVULA I GRJEŠKE IZLAZNOG TRAKTA LIJEVE KLIJETKE U DJECE – SINDROM BIKUSPIDALNE AORTOPATIJE?", Liječnički vjesnik, vol.137, br. 9-10, str. 0-0, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/172717. [Citirano: 24.10.2020.]
Sažetak . Although bicuspid aortic valve (BAV) is considered the most common congenital heart defect (CHD) in adult age, with the 0.5-2% prevalence, BAV is not part of epidemiological studies of congenital heart defects (CHD) in children. Aortic valvulogenesis disorder is part of the left ventricular outflow tract (LVOT) genetic disorders which include: hypoplastic left heart syndrome (HLHS), aortic stenosis (AS) and insufficiency (AI), dilatation of the ascending aorta (DAA), coarctation of the aorta (CoA), Shone’s syndrome (SS), and probably some other disorders. Our observations indicate that BAV related significant pathologic and hemodynamic changes occur in children already. In an 11-year long retrospective study (2000-2011) we have found 229 BAV patients, predominantly males (1.7). The most common BAV associated disorder was CoA (75 patients, 32.6%). Of all the children with BAV, 62.4% (143:229) had hemodynamic alterations on the aortic valve which manifested themselves as aortic stenosis and/or insufficiency. AS is mostly progressive and becomes hemodynamically relevant in childhood age already, while AI is mostly mild and rarely hemodynamically relevant. A large proportion of patients had isolated AS with DAA (21 or 14.7%), while most patients had combined AS and AI (29 or 20.3%). Due to morphological changes on the valve itself and on the adjoining defects, numerous interventional and cardiosurgical procedures have been performed. Their number has been growing with age, in accordance with the expected progression of pathological changes on the valve (AS, AI) or on the aorta (DAA). DAA in children with BAV was found in 76 (33.2%) patients, in various combinations with other associated LVOT anomalies. Already in childhood have the following surgical procedures on children with primary BAV diagnosis been performed : resection of CoA with T-T anastomosis was performed in 56 patients (24.5%); balloon aortic valvuloplasty in 28 patients (12.3%); commissurotomy in 19 patients (8.3%); balloon dilatation of CoA in 15 patients (6.5%); subaortic membrane resection in 11 patients (4.8%); Ross procedure in 8 patients (3.5%); resection of CoA with reconstruction in 8 patients (3.5%); valvuloplasty in 6 patients (2.6%); ascending aortoplasty in 5 patients (2.2%); mechanical valve replacement in 3 patients (1.3%); »subclavian flap« in 3 patients (1.3%); biological aortic valve replacement in 2 patients (0.9%); Bentall procedure in 1 patient (0.4%); David procedure in 1 patient (0.4%). Contribution of the study: A BAV finding in children is a predictive factor for a progressive development of morphological changes in various LVOT parts, requiring that in some patients hemodynamic repercussions be removed already in childhood. Conclusion: The term valvular aortopathy, that is bicuspid aortic valve syndrome, should be in use already for children, and the anomaly should be included in epidemiological CHD research.