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Professional paper


Krešimir Galešić
Ivica Horvatić
Mario Ilić
Martin Ćuk
Matija Crnogorac
Danica Galešić Ljubanović

Fulltext: croatian, pdf (858 KB) pages 0-0 downloads: 836* cite
APA 6th Edition
Galešić, K., Horvatić, I., Ilić, M., Ćuk, M., Crnogorac, M. & Galešić Ljubanović, D. (2016). HIPOKALIEMIJSKA METABOLIČKA ALKALOZA: PRIKAZ 6 SLUČAJEVA. Liječnički vjesnik, 138 (9-10), 0-0. Retrieved from
MLA 8th Edition
Galešić, Krešimir, et al. "HIPOKALIEMIJSKA METABOLIČKA ALKALOZA: PRIKAZ 6 SLUČAJEVA." Liječnički vjesnik, vol. 138, no. 9-10, 2016, pp. 0-0. Accessed 19 Jun. 2021.
Chicago 17th Edition
Galešić, Krešimir, Ivica Horvatić, Mario Ilić, Martin Ćuk, Matija Crnogorac and Danica Galešić Ljubanović. "HIPOKALIEMIJSKA METABOLIČKA ALKALOZA: PRIKAZ 6 SLUČAJEVA." Liječnički vjesnik 138, no. 9-10 (2016): 0-0.
Galešić, K., et al. (2016). 'HIPOKALIEMIJSKA METABOLIČKA ALKALOZA: PRIKAZ 6 SLUČAJEVA', Liječnički vjesnik, 138(9-10), pp. 0-0. Available at: (Accessed 19 June 2021)
Galešić K, Horvatić I, Ilić M, Ćuk M, Crnogorac M, Galešić Ljubanović D. HIPOKALIEMIJSKA METABOLIČKA ALKALOZA: PRIKAZ 6 SLUČAJEVA. Liječnički vjesnik [Internet]. 2016 [cited 2021 June 19];138(9-10):0-0. Available from:
K. Galešić, I. Horvatić, M. Ilić, M. Ćuk, M. Crnogorac and D. Galešić Ljubanović, "HIPOKALIEMIJSKA METABOLIČKA ALKALOZA: PRIKAZ 6 SLUČAJEVA", Liječnički vjesnik, vol.138, no. 9-10, pp. 0-0, 2016. [Online]. Available: [Accessed: 19 June 2021]

In this article six patients with hypokalemic metabolic alkalosis, classified as Bartter or Gitelman syndrome are presented. Both syndromes result from different gene mutation inducing impaired function of the transporters involved in sodium, chloride and potassium reapsorption in thick ascending limb of the loop of Henle and distal convoluted tubules. These syndromes typically present with hypokalemia, metabolic alkalosis, hyperreninemic hyperaldosteronism without hypertension, polyuria and muscle weakness. Other clinical characteristics may vary considerably, depending on the gene expression. Correct diagnosis is only possible using expensive and not-routinely available genetic testing. Routine laboratory tests, especially those considering serum and urine electrolytes, can help in recognizing these syndromes and therefore in timely beginning of treatment. The most important distinctive laboratory findings are serum magnesium concentration and urine calcium excretion. In Bartter syndrome typically there is hypercalciuria with or without hypomagnesemia, while in Gitelman syndrome typical findings are hypocalciuria and hypomagnesemia. Recognizing and treating these patients is important due to possible increased morbidity and mortality induced by severe electrolyte imbalance.

Bartter syndrome – diagnosis, genetics, therapy; Gitelman syndrome – diagnosis, genetics, therapy; Alkalosis – etiology, diagnosis, genetics; Hypokalemia – etiology, diagnosis, genetics; Renal tubular transport, inborn errors – genetics; Membrane transport proteins – genetics; Mutation; Kidney tubules, distal – pathology; Loop of henle – metabolism, pathology; Juxtaglomerular apparatus – pathology; Magnesium – blood; Calcium – urine; Hyperaldosteronism – etiologija

Hrčak ID: 172888



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