Liječnički vjesnik, Vol. 138 No. 9-10, 2016.
Stručni rad
HEPATITIS E IN CROATIA – GUIDELINES FOR DIAGNOSIS AND TREATMENT
Oktavija Đaković Rode
Lorena Jemeršić
Adriana Vince
Sažetak
Hepatitis E is attributed great attention as an emerging worldwide-distributed zoonosis. The clinical presentation varies from severe fulminant in underdeveloped to milder forms of diagnostically unrecognized hepatitis cases in developed countries. Chronic hepatitis E is more often described in subjects with transplanted solid organs and HIV disease. The diagnosis of hepatitis E is established by determination of anti-HEV IgM and IgG with Western blot confirmation and detection of HEV RNA. In Croatia, the first case of indigenous disease caused by HEV genotype 3 (HEV-3) was detected in 2012. In this paper we present current knowledge on hepatitis E supplemented by own results obtained at the University Hospital for Infectious Diseases in Zagreb and guidelines for diagnosis and treatment of immunocompetent and immunocompromised individuals. In the period from 2011-2014, HEV was tested in 1107 patients, of whom 117 (10.6%) had anti-HEV antibodies. Acute HEV infection was diagnosed in 25 (2.3%) patients. Considering the prevalence of antibodies we can conclude that HEV diagnostics should be included in the diagnostic panel for patients with elevated aminotransferases.
Ključne riječi
Hepatitis E – epidemiology, virology, diagnosis, therapy; Hepatitis E virus – genetics, pathogenicity, immnunology, isolation and purifi cation; Antibodies, viral – immunology, blood; Immunoglobulin G – blood; Immunoglobulin M – blood; RNA, viral – blood; Zoonoses – virology, transmission; Croatia – epidemiology; Practice guidelines as topic
Hrčak ID:
172892
URI
Datum izdavanja:
2.11.2016.
Posjeta: 1.969 *