Pregledni rad
https://doi.org/10.15255/KUI.2015.051
3-Hydroxypyridin-4-ones (Part II): Biological Application as Iron Chelating Agents
Željka Car
orcid.org/0000-0002-7301-6615
; Zavod za organsku kemiju, Kemijski odsjek, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu, Horvatovac 102A, 10 000 Zagreb
Vesna Petrović Peroković
; Zavod za organsku kemiju, Kemijski odsjek, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu, Horvatovac 102A, 10 000 Zagreb
Srđanka Tomić Pisarović
; Zavod za organsku kemiju, Kemijski odsjek, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu, Horvatovac 102A, 10 000 Zagreb
Sažetak
Selectivity towards trivalent metal cations, especially Fe(III), is the primary basis of a number of 3-hydroxypyridin-4-ones’ biological activities. These compounds have high potential in the treatment of iron overload diseases, in various blood pathologies such as thalassemia and hemochromatosis, as well as in the treatment of neurodegenerative diseases, such as Alzheimer’s disease. Beside deferiprone, the only 3-hydroxypyridin-4-one based iron(III) chelating agent which has been used clinically for more than 30 years, this review will also present other most significant and potentially biologically active chelators with 3-hydroxypyridin-4-one core.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ključne riječi
3-hydroxypyridin-4-ones; iron(III); chelation based therapeutics; deferiprone; thalassemia; Alzheimer’s disease
Hrčak ID:
173703
URI
Datum izdavanja:
5.2.2017.
Posjeta: 1.600 *