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Serum Cytokine Profiles in Infants with Atopic Dermatitis

Asuman Gürkan
Ayşegül Atak-Yücel
Cemile Sönmez
Şennur Keleş
İlknur Bostancı

Fulltext: english, PDF (221 KB) pages 268-268 downloads: 396* cite
APA 6th Edition
Gürkan, A., Atak-Yücel, A., Sönmez, C., Keleş, Ş. & Bostancı, İ. (2016). Serum Cytokine Profiles in Infants with Atopic Dermatitis. Acta Dermatovenerologica Croatica, 24 (4), 268-268. Retrieved from https://hrcak.srce.hr/173945
MLA 8th Edition
Gürkan, Asuman, et al. "Serum Cytokine Profiles in Infants with Atopic Dermatitis." Acta Dermatovenerologica Croatica, vol. 24, no. 4, 2016, pp. 268-268. https://hrcak.srce.hr/173945. Accessed 3 Dec. 2021.
Chicago 17th Edition
Gürkan, Asuman, Ayşegül Atak-Yücel, Cemile Sönmez, Şennur Keleş and İlknur Bostancı. "Serum Cytokine Profiles in Infants with Atopic Dermatitis." Acta Dermatovenerologica Croatica 24, no. 4 (2016): 268-268. https://hrcak.srce.hr/173945
Harvard
Gürkan, A., et al. (2016). 'Serum Cytokine Profiles in Infants with Atopic Dermatitis', Acta Dermatovenerologica Croatica, 24(4), pp. 268-268. Available at: https://hrcak.srce.hr/173945 (Accessed 03 December 2021)
Vancouver
Gürkan A, Atak-Yücel A, Sönmez C, Keleş Ş, Bostancı İ. Serum Cytokine Profiles in Infants with Atopic Dermatitis. Acta Dermatovenerol Croat. [Internet]. 2016 [cited 2021 December 03];24(4):268-268. Available from: https://hrcak.srce.hr/173945
IEEE
A. Gürkan, A. Atak-Yücel, C. Sönmez, Ş. Keleş and İ. Bostancı, "Serum Cytokine Profiles in Infants with Atopic Dermatitis", Acta Dermatovenerologica Croatica, vol.24, no. 4, pp. 268-268, 2016. [Online]. Available: https://hrcak.srce.hr/173945. [Accessed: 03 December 2021]

Abstracts

Atopic dermatitis (AD) in infancy is believed to have distinct features as compared to AD in other age groups, and little is known about cytokine production in infants with AD. We aimed to measure the serum cytokine levels of infants with atopic dermatitis and evaluate the association of new anti-inflammatory cytokines with the disease. Eighty-one infant patients with AD and 52 healthy controls were involved in this study. The serum levels of major pro- and anti-inflammatory cytokines of the T-helper (Th) subtypes, as well as more recently defined interleukins (IL-27, IL-35, and IL-37), were measured using the ELISA method. The serum levels of IL-35, IL-5, and interferon (IFN)-γ were found to be significantly higher, while the levels of transforming growth factor (TGF)-β1 and IL-13 were found to be significantly lower in patients with AD as compared to controls. There was no statistically significant correlation between serum cytokine levels and objective SCORAD index or total immunoglobulin (Ig) E levels. We did not observe prominent serum Th2 polarization in atopic infants. The immunopathogenesis of atopy onset at an early age may be more complicated than that at older ages. 

 

Keywords
atopic dermatitşs; cytokines; interleukins; infancy

Hrčak ID: 173945

URI
https://hrcak.srce.hr/173945

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