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CAN WE REVERSE NEGATIVE IMPACT OF PROLONGED MECHANICAL VENTILATION ON RESPIRATORY MUSCLES?

Luka Camlek ; University Clinic for Pulmonary and Allergic Diseases Golnik

Puni tekst: engleski, pdf (117 KB) str. 23-26 preuzimanja: 153* citiraj
APA 6th Edition
Camlek, L. (2017). CAN WE REVERSE NEGATIVE IMPACT OF PROLONGED MECHANICAL VENTILATION ON RESPIRATORY MUSCLES?. Physiotherapia Croatica, 14(Suppl) (1.), 23-26. Preuzeto s https://hrcak.srce.hr/174010
MLA 8th Edition
Camlek, Luka. "CAN WE REVERSE NEGATIVE IMPACT OF PROLONGED MECHANICAL VENTILATION ON RESPIRATORY MUSCLES?." Physiotherapia Croatica, vol. 14(Suppl), br. 1., 2017, str. 23-26. https://hrcak.srce.hr/174010. Citirano 12.12.2019.
Chicago 17th Edition
Camlek, Luka. "CAN WE REVERSE NEGATIVE IMPACT OF PROLONGED MECHANICAL VENTILATION ON RESPIRATORY MUSCLES?." Physiotherapia Croatica 14(Suppl), br. 1. (2017): 23-26. https://hrcak.srce.hr/174010
Harvard
Camlek, L. (2017). 'CAN WE REVERSE NEGATIVE IMPACT OF PROLONGED MECHANICAL VENTILATION ON RESPIRATORY MUSCLES?', Physiotherapia Croatica, 14(Suppl)(1.), str. 23-26. Preuzeto s: https://hrcak.srce.hr/174010 (Datum pristupa: 12.12.2019.)
Vancouver
Camlek L. CAN WE REVERSE NEGATIVE IMPACT OF PROLONGED MECHANICAL VENTILATION ON RESPIRATORY MUSCLES?. Physiotherapia Croatica [Internet]. 2017 [pristupljeno 12.12.2019.];14(Suppl)(1.):23-26. Dostupno na: https://hrcak.srce.hr/174010
IEEE
L. Camlek, "CAN WE REVERSE NEGATIVE IMPACT OF PROLONGED MECHANICAL VENTILATION ON RESPIRATORY MUSCLES?", Physiotherapia Croatica, vol.14(Suppl), br. 1., str. 23-26, 2017. [Online]. Dostupno na: https://hrcak.srce.hr/174010. [Citirano: 12.12.2019.]

Sažetak
BACKGROUND: Prolonged mechanical ventilation
although saving lives, can have decremental eff ect on repiratory
muscles, mainly diaphragm. Th e aim of this article
is to summarize the mechanisms of respiratory muscle
atrophy and possible interventions for atrophy reversal.Discussion
Systematic literature review.
CONCLUSIONS: Intensive care unit physicians are aware
of negative impact of nechanical ventilation on lung parenchyma.
But recently more and more evidence is accumulating,
that mechanical ventilation provides isuffi cient stress
on respiratory muscles and with that promoting diaphragm
atrophy and contractile dysfunction which leads to
prolonged weaning and ventilator dependency. Research
on animals has documented that inactivity of diaphragm
induces injury and atrophy of muscle cells. Studies on
patients on controlled mechanical mentilation confi rmed
this phenomena in humans. Th e mechanisms of diaphragm
atrophy are complex an include oxidative injury,
decreased protein turnover, gene expresson and cell signaling,
and induction of diaphragm muscle cell apoptosis.
Diaphragm atrophy and dysfunction leads to prolonged
mechanical ventilation, ventilator dependency and also to
increased mortality.
Th is phenomena can be in some patients reversed with respiratory
muscle training. Th e results between studies vary,
mainly beacuse in they used diff erent methods of respiratory
muscle training, and included the patients with diff erent
diseases. Future studies will show which patients will
have the greatest benefi t from respiratory muscle trainig and
which trainig regime is best for muscle growth induction.

Ključne riječi
diaphragm; respiratory muscles; mechanical ventilation; diaphragm weakness; inspiratory muscle training; respiratory physiotherapy

Hrčak ID: 174010

URI
https://hrcak.srce.hr/174010

Posjeta: 214 *