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Review article

Cyclodextrins: Application in different routes of drug administration

SHYAM SHIMPI
BHASKAR CHAUHAN
PRAJAKTA SHIMPI

Fulltext: english, pdf (107 KB) pages 139-156 downloads: 5.128* cite
APA 6th Edition
SHIMPI, S., CHAUHAN, B. & SHIMPI, P. (2005). Cyclodextrins: Application in different routes of drug administration. Acta Pharmaceutica, 55 (2), 139-156. Retrieved from https://hrcak.srce.hr/16752
MLA 8th Edition
SHIMPI, SHYAM, et al. "Cyclodextrins: Application in different routes of drug administration." Acta Pharmaceutica, vol. 55, no. 2, 2005, pp. 139-156. https://hrcak.srce.hr/16752. Accessed 20 Oct. 2019.
Chicago 17th Edition
SHIMPI, SHYAM, BHASKAR CHAUHAN and PRAJAKTA SHIMPI. "Cyclodextrins: Application in different routes of drug administration." Acta Pharmaceutica 55, no. 2 (2005): 139-156. https://hrcak.srce.hr/16752
Harvard
SHIMPI, S., CHAUHAN, B., and SHIMPI, P. (2005). 'Cyclodextrins: Application in different routes of drug administration', Acta Pharmaceutica, 55(2), pp. 139-156. Available at: https://hrcak.srce.hr/16752 (Accessed 20 October 2019)
Vancouver
SHIMPI S, CHAUHAN B, SHIMPI P. Cyclodextrins: Application in different routes of drug administration. Acta Pharm. [Internet]. 2005 [cited 2019 October 20];55(2):139-156. Available from: https://hrcak.srce.hr/16752
IEEE
S. SHIMPI, B. CHAUHAN and P. SHIMPI, "Cyclodextrins: Application in different routes of drug administration", Acta Pharmaceutica, vol.55, no. 2, pp. 139-156, 2005. [Online]. Available: https://hrcak.srce.hr/16752. [Accessed: 20 October 2019]

Abstracts
The objective of this review article is to explain the use of cyclodextrin in the different routes of drug administration. The article gives the chemistry of cyclodextrins and addresses the issue of the mechanism of drug release from cyclodextrin complexes. Dilution, competitive displacement, protein binding, change in ionic strength and temperature and drug uptake by tissues are the different release mechanisms of the drug from the drug-cyclodextrin complex discussed here. Use and its limitations in the different drug delivery systems like nasal, ophthalmic, transdermal and rectal drug delivery are explained. The application of the cyclodextrins in the oral drug delivery is detailed in this review. Many studies have shown that cyclodextrins are used as useful additives in the routes of drug administration because of increased aqueous solubility, stability, bioavailability and reduced drug irritation.

Keywords
cyclodextrins; release mechanism; nasal drug delivery; ophthalmic drug delivery; transdermal drug delivery; rectal drug delivery; oral drug delivery

Hrčak ID: 16752

URI
https://hrcak.srce.hr/16752

[croatian]

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