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Original scientific paper

Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation

ANAND KUMAR SRIVASTAVA
DEVENDRA NARAYANRAO RIDHURKAR
SAURABH WADHWA

Fulltext: english, pdf (141 KB) pages 277-285 downloads: 3.741* cite
APA 6th Edition
SRIVASTAVA, A.K., RIDHURKAR, D.N. & WADHWA, S. (2005). Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation. Acta Pharmaceutica, 55 (3), 277-285. Retrieved from https://hrcak.srce.hr/16764
MLA 8th Edition
SRIVASTAVA, ANAND KUMAR, et al. "Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation." Acta Pharmaceutica, vol. 55, no. 3, 2005, pp. 277-285. https://hrcak.srce.hr/16764. Accessed 11 Jul. 2020.
Chicago 17th Edition
SRIVASTAVA, ANAND KUMAR, DEVENDRA NARAYANRAO RIDHURKAR and SAURABH WADHWA. "Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation." Acta Pharmaceutica 55, no. 3 (2005): 277-285. https://hrcak.srce.hr/16764
Harvard
SRIVASTAVA, A.K., RIDHURKAR, D.N., and WADHWA, S. (2005). 'Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation', Acta Pharmaceutica, 55(3), pp. 277-285. Available at: https://hrcak.srce.hr/16764 (Accessed 11 July 2020)
Vancouver
SRIVASTAVA AK, RIDHURKAR DN, WADHWA S. Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation. Acta Pharm. [Internet]. 2005 [cited 2020 July 11];55(3):277-285. Available from: https://hrcak.srce.hr/16764
IEEE
A.K. SRIVASTAVA, D.N. RIDHURKAR and S. WADHWA, "Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation", Acta Pharmaceutica, vol.55, no. 3, pp. 277-285, 2005. [Online]. Available: https://hrcak.srce.hr/16764. [Accessed: 11 July 2020]

Abstracts
The present study involves preparation and evaluation of floating microspheres with cimetidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron microscopy, respectively. In vitro drug release studies were performed and drug release kinetics was evaluated using the linear regression method. Effects of stirring rate during preparation, polymer concentration, solvent composition and dissolution medium on the size of microspheres and drug release were also observed. The prepared microspheres exhibited prolonged drug release (~ 8 h) and remained buoyant for > 10 h. The mean particle size increased and drug release rate increased at higher polymer concentration. In vitro studies demonstrated diffusion-controlled drug release from the microspheres. No significant effect of the stirring rate during preparation on drug release was observed.

Keywords
floating microspheres; cimetidine; solvent evaporation; in vitro release; bioavailability

Hrčak ID: 16764

URI
https://hrcak.srce.hr/16764

[croatian]

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