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Acta Pharmaceutica, Vol. 54 No. 2, 2004.

Izvorni znanstveni članak

Syntheses and characterisation of N,N'-biscarbazolyl azine and N,N'-carbazolyl hydrazine derivatives and their antimicrobial studies

ISRAVEL ANTONY DANISH
KARNAM JAYARAMPILLAI
RAJENDRA PRASAD

Puni tekst: engleski, pdf (99 KB) str. 133-142 preuzimanja: 435* citiraj
APA 6th Edition
ANTONY DANISH, I., JAYARAMPILLAI, K. i PRASAD, R. (2004). Syntheses and characterisation of N,N'-biscarbazolyl azine and N,N'-carbazolyl hydrazine derivatives and their antimicrobial studies. Acta Pharmaceutica, 54 (2), 133-142. Preuzeto s https://hrcak.srce.hr/16821
MLA 8th Edition
ANTONY DANISH, ISRAVEL, et al. "Syntheses and characterisation of N,N'-biscarbazolyl azine and N,N'-carbazolyl hydrazine derivatives and their antimicrobial studies." Acta Pharmaceutica, vol. 54, br. 2, 2004, str. 133-142. https://hrcak.srce.hr/16821. Citirano 19.02.2019.
Chicago 17th Edition
ANTONY DANISH, ISRAVEL, KARNAM JAYARAMPILLAI i RAJENDRA PRASAD. "Syntheses and characterisation of N,N'-biscarbazolyl azine and N,N'-carbazolyl hydrazine derivatives and their antimicrobial studies." Acta Pharmaceutica 54, br. 2 (2004): 133-142. https://hrcak.srce.hr/16821
Harvard
ANTONY DANISH, I., JAYARAMPILLAI, K., i PRASAD, R. (2004). 'Syntheses and characterisation of N,N'-biscarbazolyl azine and N,N'-carbazolyl hydrazine derivatives and their antimicrobial studies', Acta Pharmaceutica, 54(2), str. 133-142. Preuzeto s: https://hrcak.srce.hr/16821 (Datum pristupa: 19.02.2019.)
Vancouver
ANTONY DANISH I, JAYARAMPILLAI K, PRASAD R. Syntheses and characterisation of N,N'-biscarbazolyl azine and N,N'-carbazolyl hydrazine derivatives and their antimicrobial studies. Acta Pharm. [Internet]. 2004 [pristupljeno 19.02.2019.];54(2):133-142. Dostupno na: https://hrcak.srce.hr/16821
IEEE
I. ANTONY DANISH, K. JAYARAMPILLAI i R. PRASAD, "Syntheses and characterisation of N,N'-biscarbazolyl azine and N,N'-carbazolyl hydrazine derivatives and their antimicrobial studies", Acta Pharmaceutica, vol.54, br. 2, str. 133-142, 2004. [Online]. Dostupno na: https://hrcak.srce.hr/16821. [Citirano: 19.02.2019.]

Sažetak
Reaction of 1-oxo-1,2,3,4-tetrahydrocarbazoles (1a-e) with hydrazine hydrate in absolute ethanol afforded N,N'-biscarbazolylazine derivatives (2a-e). Treatment of 1-oxo-1,2,3,4-tetrahydrocarbazoles (1a-e) with hydroxylamine hydrochloride in ethanol with a catalytic amount of pyridine resulted in the formation of 1-hydroxyimino-1,2,3,4-tetrahydrocarbazoles (3a-e). Reduction of 3 with hydrazine hydrate in the presence of palladized carbon afforded N,N'-carbazolyl hydrazine derivatives (4a-e). The newly formed compounds were characterized by IR, 1H NMR, mass spectra and by elemental analysis. All compounds proved to have great potentialities as antibacterial and antifungal agents due to the presence of the azine or the hydrazine group. Particularly, the chloro substituted derivatives 2e and 4e showed excellent antibacterial and antifungal activity.

Ključne riječi
1-oxo-1,2,3,4-tetrahydrocarbazoles; 1-hydroxyimino-1,2,3,4-tetrahydrocarbazoles; N,N'-biscarbazolylazines, N,N'-carbazolylhydrazines; antibacterial; antifungal activity

Hrčak ID: 16821

URI
https://hrcak.srce.hr/16821

[hrvatski]

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