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THE ASSOCIATION OF PINEAL GLAND VOLUME AND BODY MASS IN OBESE AND NORMAL WEIGHT INDIVIDUALS: A PILOT STUDY

Martin Grosshans ; Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany
Christian Vollmert ; Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany
Sabine Vollstaedt-Klein ; Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany
Ingo Nolte ; Department of Neuroradiology, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany
Emanuel Schwarz ; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany
Xenija Wagner ; Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany
Markus Leweke ; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany
Jochen Mutschler ; Center of Addictive Disorders, Department of Psychiatry, Psychothrapy and Psychosomatics, Psychiatric University Hospital, Zürich, Switzerland; Privatklinik Meiringen, Willingen, 3860 Meiringen, Switzerland
Falk Kiefer ; Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany
Jan Malte Bumb ; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany

Sažetak

Background: In obese individuals impaired sleep and neuroendocrine alterations such as melatonin deficits are associated with
circadian rhythm disruption, altered circadian clock gene expression, and bright light at night. While the relation of pineal gland
volume (PGV) and melatonin levels has recently been documented in humans, surprisingly little is known about the possible
interference of the PGV and the pathophysiology of obesity in humans.
Subjects and methods: We therefore compared the PGV of obese with non-obese individuals; both groups were matched by age
and gender. Volumetric analyses were performed on the basis of 3 Tesla high resolution Magnetic Resonance Imaging (MRI).
Results: We found, that the PGV was significantly smaller in obese individuals than in lean controls (P=0.036). Moreover, PGV
and waist-hip ratio showed a significant negative association in controls (P=0.018, rS=-0.602) whereas no association of both
variables was found in obese individuals (P=0.856, rS=-0.051).
Conclusions: Thus, the current pilot investigation suggests that pineal gland function, reflected by PGV might be involved in the
energy homeostasis and pathophysiological mechanisms that contribute to the development and the maintenance of obesity in
humans. Moreover, our data supports the notion that the replacement of melatonin deficits might be a novel strategy in the treatment
of obesity.

Ključne riječi

pineal gland; obesity; body mass; BMI; MPRAGE; MRI, obesity

Hrčak ID:

176254

URI

https://hrcak.srce.hr/176254

Datum izdavanja:

15.9.2016.

Posjeta: 1.240 *