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SENSORY GATING DEFICITS AND IMPAIRED QUALITY OF LIFE IN PATIENTS WITH SCHIZOPHRENIA: A PRELIMINARY STUDY

Jean-Arthur Micoulaud-Franchi ; Services d'explorations fonctionnelles du système nerveux, Clinique du sommeil, CHU de Bordeaux, Bordeaux, France; USR CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, Bordeaux, France
Mélanie Faugere ; APHM, Hôpital de la Conception, Service de Psychiatrie Universitaire du Professeur Christophe Lançon, Marseille, France; Aix Marseille Université, Santé Publique, Maladies chroniques et Qualité de Vie, SPMC UPRES EA3279, Marseille, France
Laurent Boyer ; APHM, Hôpital de la Conception, Service de Psychiatrie Universitaire du Professeur Christophe Lançon, Marseille, France; Aix Marseille Université, Santé Publique, Maladies chroniques et Qualité de Vie, SPMC UPRES EA3279, Marseille, France
Michel Cermolacce ; Pôle de Psychiatrie “Solaris”, Centre Hospitalier Universitaire de Sainte-Marguerite, Marseille, France; Laboratoire de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille Université, Site St Charles, Marseille cedex 3, France
Guillaume Fond ; INSERM U955, Translational Psychiatry team, Créteil, France; Université Paris Est, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France
Raphaëlle Richieri ; APHM, Hôpital de la Conception, Service de Psychiatrie Universitaire du Professeur Christophe Lançon, Marseille, France; Aix Marseille Université, Santé Publique, Maladies chroniques et Qualité de Vie, SPMC UPRES EA3279, Marseille, France
Jean Vion-Dury ; Pôle de Psychiatrie “Solaris”, Centre Hospitalier Universitaire de Sainte-Marguerite, Marseille, France; Laboratoire de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille Université, Site St Charles, Marseille cedex 3, France
Christophe Lancon ; APHM, Hôpital de la Conception, Service de Psychiatrie Universitaire du Professeur Christophe Lançon, Marseille, France; Aix Marseille Université, Santé Publique, Maladies chroniques et Qualité de Vie, SPMC UPRES EA3279, Marseille, France

Sažetak

Background: New determinants of quality of life in schizophrenia need to be identified. As sensory gating deficit is core
impairment in schizophrenia, the present study hypothesized that sensory gating deficit is a determinant of impaired quality of life in
schizophrenia. This study therefore investigated the relationship between sensory gating deficit and quality of life in patients with
schizophrenia after adjusting for key confounding factors.
Subjects and methods: Sensory gating was assessed with the auditory event-related potential method by measuring P50
amplitude changes in a double-click conditioning-testing procedure, perceptual impairments related to sensory gating deficit was
assessed with the SGI questionnaire and quality of life was assessed with the SQoL 18 questionnaire in 39 patients with
schizophrenia.
Results: Patients with sensory gating deficit (n=14) had a lower subjective quality of life on the psychological well-being
dimension evaluated with SQoL 18 questionnaire (p=0.008) compared to those without it (n=25). This result remained significant
(B=-0.45, Wald=4.84, p=0.02) after taking into account 7 potential confounding factors (gender, age, level of education, duration of
disorder, positive symptoms, depressive symptoms and anxiety symptoms). Poorer psychological well-being was related to a higher
score on the SGI (rho=-0.40, p=0.01), in particular on the Distractibility dimension (rho=-0.47, p=0.001).
Conclusions: These findings suggest that sensory gating deficit may be a determinant of impaired quality of life in
schizophrenia. Further studies are needed to address the causal relationship between sensory gating deficit, perceptual impairments,
attentional deficit and impaired quality of life in schizophrenia in order to act more efficiently on the quality of life of patients with
this disorder.

Ključne riječi

schizophrenia; quality of life; sensory gating; P50 suppression; perceptual impairments

Hrčak ID:

176257

URI

https://hrcak.srce.hr/176257

Datum izdavanja:

15.9.2016.

Posjeta: 731 *