Acta Pharmaceutica, Vol. 54 No. 3, 2004.
Izvorni znanstveni članak
Poly(lactide-co-glycolide) microparticles as systems for controlled release of proteins - Preparation and characterization
ALEKSANDRA PORJAZOSKA
KATERINA GORACINOVA
KRISTINA MLADENOVSKA
MARIJA GLAVAŠ
MAJA SIMONOVSKA
EMILIJA IVANOVSKA JANJEVIĆ
MAJA CVETKOVSKA
Sažetak
Poly(DL-lactide-co-glycolide) (PDLLGA) and poly(L-lactide-co-glycolide) (PLLGA) copolymers were prepared by bulk ring opening polymerization of lactide and glycolide and characterized by GPC, FTIR, 1H NMR and DSC. Copolymers with different molar masses at a constant lactide/glycolide ratio were used for preparation of bovine serum albumin (BSA)-loaded microparticles by the double emulsion w/o/w method. The influence of the copolymer molar mass and composition on the microparticle morphology, size, yield, degradation rate, BSA-loading efficiency and BSA release profile were studied. For microparticles prepared from PDLLGA copolymers, a biphasic profile for BSA release was found and for those made from PLLGA copolymers the release profile was typically triphasic; both of them were characterized by high initial burst release. Possible reasons for such behavior are discussed.
Ključne riječi
poly(lactide-co-glycolide); microparticles; protein; in vitro release
Hrčak ID:
16865
URI
Datum izdavanja:
1.9.2004.
Posjeta: 2.912 *