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Design and in vitro evaluation of new drug-in-adhesive formulations of fentanyl transdermal patches

AMIR MEHDIZADEH
TAYEBE TOLIATE
MOHAMMAD REZA ROUINI
SHARYAR ABASHZADEH
FARID DORKOOSH

Puni tekst: engleski, pdf (150 KB) str. 301-317 preuzimanja: 2.893* citiraj
APA 6th Edition
MEHDIZADEH, A., TOLIATE, T., REZA ROUINI, M., ABASHZADEH, S. i DORKOOSH, F. (2004). Design and in vitro evaluation of new drug-in-adhesive formulations of fentanyl transdermal patches. Acta Pharmaceutica, 54 (4), 301-317. Preuzeto s https://hrcak.srce.hr/16906
MLA 8th Edition
MEHDIZADEH, AMIR, et al. "Design and in vitro evaluation of new drug-in-adhesive formulations of fentanyl transdermal patches." Acta Pharmaceutica, vol. 54, br. 4, 2004, str. 301-317. https://hrcak.srce.hr/16906. Citirano 19.06.2019.
Chicago 17th Edition
MEHDIZADEH, AMIR, TAYEBE TOLIATE, MOHAMMAD REZA ROUINI, SHARYAR ABASHZADEH i FARID DORKOOSH. "Design and in vitro evaluation of new drug-in-adhesive formulations of fentanyl transdermal patches." Acta Pharmaceutica 54, br. 4 (2004): 301-317. https://hrcak.srce.hr/16906
Harvard
MEHDIZADEH, A., et al. (2004). 'Design and in vitro evaluation of new drug-in-adhesive formulations of fentanyl transdermal patches', Acta Pharmaceutica, 54(4), str. 301-317. Preuzeto s: https://hrcak.srce.hr/16906 (Datum pristupa: 19.06.2019.)
Vancouver
MEHDIZADEH A, TOLIATE T, REZA ROUINI M, ABASHZADEH S, DORKOOSH F. Design and in vitro evaluation of new drug-in-adhesive formulations of fentanyl transdermal patches. Acta Pharm. [Internet]. 2004 [pristupljeno 19.06.2019.];54(4):301-317. Dostupno na: https://hrcak.srce.hr/16906
IEEE
A. MEHDIZADEH, T. TOLIATE, M. REZA ROUINI, S. ABASHZADEH i F. DORKOOSH, "Design and in vitro evaluation of new drug-in-adhesive formulations of fentanyl transdermal patches", Acta Pharmaceutica, vol.54, br. 4, str. 301-317, 2004. [Online]. Dostupno na: https://hrcak.srce.hr/16906. [Citirano: 19.06.2019.]

Sažetak
The present research was designed to evaluate different matrix, drug-in-adhesive and reservoir formulations of fentanyl transdermal patches. The target was to design drug-in-adhesive patches (DIAPs); a full factorial design was used. Different types and amounts of liquid, pressure-sensitive adhesives (PSAs) were used and evaluated with respect to drug release and adhesive properties. A very simple but precise method, the simplified peel 180° test, was developed to measure and compare adhesive properties of transdermal patches. The results showed that release kinetics obeyed the square root of time or Higuchi model, indicating the diffusion controlled release mechanism. It was found that the amount of fentanyl needed for each 10 cm2 three-days DIAP should be 3.3 mg. The respective amounts for reservoir and matrix patches were 2.5 and 5 mg. It was concluded that acrylic PSAs showed the best adhesion and release properties.

Ključne riječi
fentanyl; transdermal drug delivery systems; patches; drug release

Hrčak ID: 16906

URI
https://hrcak.srce.hr/16906

[hrvatski]

Posjeta: 3.722 *