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Acta Pharmaceutica, Vol. 54 No. 4, 2004.

Izvorni znanstveni članak

Healing potential of Anogeissus latifolia for dermal wounds in rats

RAGHAVAN GOVINDARAJAN
MADHAVAN VIJAYAKUMAR
CHANDANA VENKATESHWARA RAO
ANNIE SHIRWAIKAR
SHANTA MEHROTRA
PALPU PUSHPANGADAN

Puni tekst: engleski, pdf (146 KB) str. 331-338 preuzimanja: 1.743* citiraj
APA 6th Edition
GOVINDARAJAN, R., VIJAYAKUMAR, M., VENKATESHWARA RAO, C., SHIRWAIKAR, A., MEHROTRA, S. i PUSHPANGADAN, P. (2004). Healing potential of Anogeissus latifolia for dermal wounds in rats. Acta Pharmaceutica, 54 (4), 331-338. Preuzeto s https://hrcak.srce.hr/16908
MLA 8th Edition
GOVINDARAJAN, RAGHAVAN, et al. "Healing potential of Anogeissus latifolia for dermal wounds in rats." Acta Pharmaceutica, vol. 54, br. 4, 2004, str. 331-338. https://hrcak.srce.hr/16908. Citirano 19.02.2019.
Chicago 17th Edition
GOVINDARAJAN, RAGHAVAN, MADHAVAN VIJAYAKUMAR, CHANDANA VENKATESHWARA RAO, ANNIE SHIRWAIKAR, SHANTA MEHROTRA i PALPU PUSHPANGADAN. "Healing potential of Anogeissus latifolia for dermal wounds in rats." Acta Pharmaceutica 54, br. 4 (2004): 331-338. https://hrcak.srce.hr/16908
Harvard
GOVINDARAJAN, R., et al. (2004). 'Healing potential of Anogeissus latifolia for dermal wounds in rats', Acta Pharmaceutica, 54(4), str. 331-338. Preuzeto s: https://hrcak.srce.hr/16908 (Datum pristupa: 19.02.2019.)
Vancouver
GOVINDARAJAN R, VIJAYAKUMAR M, VENKATESHWARA RAO C, SHIRWAIKAR A, MEHROTRA S, PUSHPANGADAN P. Healing potential of Anogeissus latifolia for dermal wounds in rats. Acta Pharm. [Internet]. 2004 [pristupljeno 19.02.2019.];54(4):331-338. Dostupno na: https://hrcak.srce.hr/16908
IEEE
R. GOVINDARAJAN, M. VIJAYAKUMAR, C. VENKATESHWARA RAO, A. SHIRWAIKAR, S. MEHROTRA i P. PUSHPANGADAN, "Healing potential of Anogeissus latifolia for dermal wounds in rats", Acta Pharmaceutica, vol.54, br. 4, str. 331-338, 2004. [Online]. Dostupno na: https://hrcak.srce.hr/16908. [Citirano: 19.02.2019.]

Sažetak
Wound healing potential of etnanolic extract of Anogeissus latifolia bark (ALE) for treatment of dermal wounds in rats was studied on excision and incision wound models. HPTLC of the total extract was recorded for the purpose of standardization. Various parameters of incision wound, viz. epithelization period, scar area, tensile strength and hydroxyproline measurements along with wound contraction, were used to evaluate the effect of A. latifolia on wound healing. The results obtained indicate that A. latifolia accelerates the wound healing process by decreasing the surface area of the wound and increasing the tensile strength. Nitrofurazone ointment was used as a positive control. Complete epithelization was observed within 15 days with ALE. Measurements of the healed area and the hydroxyproline level were in agreement. Antibacterial activity of ALE was studied against Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) compared to erythromycin and tetracycline. Moderate activity was observed against all organisms. The present study provides a scientific rationale for the traditional use of Anogeissus latifolia in the management of skin diseases such as sores, boils and itching.

Ključne riječi
Anogeissus latifolia (Combretaceae); wound healing; antibacterial activity; HPTLC

Hrčak ID: 16908

URI
https://hrcak.srce.hr/16908

[hrvatski]

Posjeta: 2.145 *