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Multicomponent Reactions and Their Libraries - a New Approach to Preparative Organic Chemistry

Ivar Ugi ; Institute for Organic Chemistry and Biochemistry, Technical University of Munich, Lichtenbergstr. 4, D-85747 Garching, Germany
Alexander Domling ; Institute for Organic Chemistry and Biochemistry, Technical University of Munich, Lichtenbergstr. 4, D-85747 Garching, Germany
Bernhard Gruber ; Institute for Organic Chemistry and Biochemistry, Technical University of Munich, Lichtenbergstr. 4, D-85747 Garching, Germany
Michael Almstetter ; Institute for Organic Chemistry and Biochemistry, Technical University of Munich, Lichtenbergstr. 4, D-85747 Garching, Germany

Puni tekst: engleski, pdf (10 MB) str. 631-647 preuzimanja: 354* citiraj
APA 6th Edition
Ugi, I., Domling, A., Gruber, B. i Almstetter, M. (1997). Multicomponent Reactions and Their Libraries - a New Approach to Preparative Organic Chemistry. Croatica Chemica Acta, 70 (2), 631-647. Preuzeto s https://hrcak.srce.hr/176963
MLA 8th Edition
Ugi, Ivar, et al. "Multicomponent Reactions and Their Libraries - a New Approach to Preparative Organic Chemistry." Croatica Chemica Acta, vol. 70, br. 2, 1997, str. 631-647. https://hrcak.srce.hr/176963. Citirano 05.03.2021.
Chicago 17th Edition
Ugi, Ivar, Alexander Domling, Bernhard Gruber i Michael Almstetter. "Multicomponent Reactions and Their Libraries - a New Approach to Preparative Organic Chemistry." Croatica Chemica Acta 70, br. 2 (1997): 631-647. https://hrcak.srce.hr/176963
Harvard
Ugi, I., et al. (1997). 'Multicomponent Reactions and Their Libraries - a New Approach to Preparative Organic Chemistry', Croatica Chemica Acta, 70(2), str. 631-647. Preuzeto s: https://hrcak.srce.hr/176963 (Datum pristupa: 05.03.2021.)
Vancouver
Ugi I, Domling A, Gruber B, Almstetter M. Multicomponent Reactions and Their Libraries - a New Approach to Preparative Organic Chemistry. Croatica Chemica Acta [Internet]. 1997 [pristupljeno 05.03.2021.];70(2):631-647. Dostupno na: https://hrcak.srce.hr/176963
IEEE
I. Ugi, A. Domling, B. Gruber i M. Almstetter, "Multicomponent Reactions and Their Libraries - a New Approach to Preparative Organic Chemistry", Croatica Chemica Acta, vol.70, br. 2, str. 631-647, 1997. [Online]. Dostupno na: https://hrcak.srce.hr/176963. [Citirano: 05.03.2021.]

Sažetak
Classical chemical syntheses from n starting materials usually require
sequences of at least n-I preparation steps, including separation
and purification of the intermediates. A perfect alternative for
the rapid syntheses of a large variety of agrichemically and pharmaceutically relevant products are one-pot syntheses by multicomponent reactions (MCR)on the basis of isocyanides. Four to seven different types of components mixed in a reaction vessel undergo the transformation to one molecule. Due to the last irreversible step that involves the isocyanides, a stable product results in quantitative yields. Using more than one representative of each type of starting materials (i.e. different isocyanides, amines, etc.) in the same vessel, all possible combinations will lead to a molecular library with hundreds and thousands of products formed according to a given reaction scheme. The design of such syntheses and the handling of the results require adequate mathematics and computer tools.

Hrčak ID: 176963

URI
https://hrcak.srce.hr/176963

Posjeta: 585 *