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Periodicum biologorum, Vol.118 No.4 March 2017.

Review article
https://doi.org/10.18054/pb.v118i4.4601

Molecular mechanisms involved in the regulation of mutation rates in bacteria

Ivan Matic

Fulltext: english, PDF (2 MB) pages 363-372 downloads: 164* cite
APA 6th Edition
Matic, I. (2016). Molecular mechanisms involved in the regulation of mutation rates in bacteria. Periodicum biologorum, 118 (4), 363-372. https://doi.org/10.18054/pb.v118i4.4601
MLA 8th Edition
Matic, Ivan. "Molecular mechanisms involved in the regulation of mutation rates in bacteria." Periodicum biologorum, vol. 118, no. 4, 2016, pp. 363-372. https://doi.org/10.18054/pb.v118i4.4601. Accessed 18 Sep. 2018.
Chicago 17th Edition
Matic, Ivan. "Molecular mechanisms involved in the regulation of mutation rates in bacteria." Periodicum biologorum 118, no. 4 (2016): 363-372. https://doi.org/10.18054/pb.v118i4.4601
Harvard
Matic, I. (2016). 'Molecular mechanisms involved in the regulation of mutation rates in bacteria', Periodicum biologorum, 118(4), pp. 363-372. doi: https://doi.org/10.18054/pb.v118i4.4601
Vancouver
Matic I. Molecular mechanisms involved in the regulation of mutation rates in bacteria. Periodicum biologorum [Internet]. 2017 Mar 17 [cited 2018 September 18];118(4):363-372. doi: https://doi.org/10.18054/pb.v118i4.4601
IEEE
I. Matic, "Molecular mechanisms involved in the regulation of mutation rates in bacteria", Periodicum biologorum, vol.118, no. 4, pp. 363-372, march 2017. [Online]. doi: https://doi.org/10.18054/pb.v118i4.4601

Abstracts

Organisms live in constantly changing environments in which, the nature, severity and frequency of the environmental stresses are very variable. Organisms possess multiple strategies for coping with the environmental fluctuations. One such strategy is modulation of mutation rates as a function of the degree of adaptation to the environment. When adaptation is limited by the available genetic variability, natural selection favors cells having high mutation rates in bacterial populations. High mutation rates can be advantageous because they increase the probability of generation of beneficial mutations. Constitutive mutator alleles are carried to high frequency through hitchhiking with beneficial mutations they generate. However, once the adaptation is achieved, the cost of deleterious mutations generated by constitutive mutator alleles reduces cellular fitness. For this reason, the possibility of adapting the mutation rate to environmental conditions is interesting from an evolutionary point of view. Stress-induced mutagenesis allows rapid adaptation to complex environmental challenges without compromising the population fitness because it reduces the overall cost of a high mutation rate. Here we review the molecular mechanisms involved in the control of modulation of mutation rates in bacteria.


Hrčak ID: 177554

URI
https://hrcak.srce.hr/177554

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