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The Synthesis and Antiviral Properties of 8- Amino-3- [(2 hydroxyethoxy)methyl]-1,2,4-triazolo- [4,3-a ]pyrazine

S. W. Schneller ; Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA
J. L. May ; Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA
E. De Clercq ; The Rega Institute, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Puni tekst: engleski, pdf (2 MB) str. 307-311 preuzimanja: 138* citiraj
APA 6th Edition
Schneller, S.W., May, J.L. i De Clercq, E. (1986). The Synthesis and Antiviral Properties of 8- Amino-3- [(2 hydroxyethoxy)methyl]-1,2,4-triazolo- [4,3-a ]pyrazine. Croatica Chemica Acta, 59 (1), 307-311. Preuzeto s https://hrcak.srce.hr/177595
MLA 8th Edition
Schneller, S. W., et al. "The Synthesis and Antiviral Properties of 8- Amino-3- [(2 hydroxyethoxy)methyl]-1,2,4-triazolo- [4,3-a ]pyrazine." Croatica Chemica Acta, vol. 59, br. 1, 1986, str. 307-311. https://hrcak.srce.hr/177595. Citirano 16.06.2021.
Chicago 17th Edition
Schneller, S. W., J. L. May i E. De Clercq. "The Synthesis and Antiviral Properties of 8- Amino-3- [(2 hydroxyethoxy)methyl]-1,2,4-triazolo- [4,3-a ]pyrazine." Croatica Chemica Acta 59, br. 1 (1986): 307-311. https://hrcak.srce.hr/177595
Harvard
Schneller, S.W., May, J.L., i De Clercq, E. (1986). 'The Synthesis and Antiviral Properties of 8- Amino-3- [(2 hydroxyethoxy)methyl]-1,2,4-triazolo- [4,3-a ]pyrazine', Croatica Chemica Acta, 59(1), str. 307-311. Preuzeto s: https://hrcak.srce.hr/177595 (Datum pristupa: 16.06.2021.)
Vancouver
Schneller SW, May JL, De Clercq E. The Synthesis and Antiviral Properties of 8- Amino-3- [(2 hydroxyethoxy)methyl]-1,2,4-triazolo- [4,3-a ]pyrazine. Croatica Chemica Acta [Internet]. 1986 [pristupljeno 16.06.2021.];59(1):307-311. Dostupno na: https://hrcak.srce.hr/177595
IEEE
S.W. Schneller, J.L. May i E. De Clercq, "The Synthesis and Antiviral Properties of 8- Amino-3- [(2 hydroxyethoxy)methyl]-1,2,4-triazolo- [4,3-a ]pyrazine", Croatica Chemica Acta, vol.59, br. 1, str. 307-311, 1986. [Online]. Dostupno na: https://hrcak.srce.hr/177595. [Citirano: 16.06.2021.]

Sažetak
The preparation of 8-amino-3-[(2-hydroxyethoxy)methyl]-1,2,4-
triazolo[4,3-a]pyrazine (IV) as an analogue of 9-[(2-hydroxyethoxy)
methyl]guanine and 9-(S)-(2,3-dihydroxypropyl)adenine is described
from the reaction of 3-chloro-2-hydrazinopyrazine (V) and ethyl 2-(2-acetoxyethoxy)thioacetimidate (IXg) followed by treatment with ammonia. Compound IV was found to lack antiviral properties towards herpes simplex I and II, vaccinia virus, vesicular stomatitis virus, measles, reovirus type 1, parainfluenza virus type 3, Sindbis virus, Coxsackie type B4 virus, and poliovirus type.

Hrčak ID: 177595

URI
https://hrcak.srce.hr/177595

Posjeta: 219 *