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Pregledni rad
https://doi.org/10.20471/acc.2016.55.04.14

Genetic etiology of primary premature ovarian insufficiency

Maja Franić-Ivanišević ; University Department of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia
Damir Franić   ORCID icon orcid.org/0000-0002-8226-2340 ; Outpatient Clinic for Obstetrics and Gynecology, Rogaška Slatina, Slovenia; School of Medicine, University of Maribor, Maribor, Slovenia
Miomira Ivović ; University Department of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia
Milina Tančić-Gajić ; University Department of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia
Ljiljana Marina ; University Department of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia
Marija Barac ; University Department of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia
Svetlana Vujović ; University Department of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia

Puni tekst: engleski, pdf (85 KB) str. 629-635 preuzimanja: 358* citiraj
APA 6th Edition
Franić-Ivanišević, M., Franić, D., Ivović, M., Tančić-Gajić, M., Marina, Lj., Barac, M. i Vujović, S. (2016). Genetic etiology of primary premature ovarian insufficiency. Acta clinica Croatica, 55 (4.), 629-635. https://doi.org/10.20471/acc.2016.55.04.14
MLA 8th Edition
Franić-Ivanišević, Maja, et al. "Genetic etiology of primary premature ovarian insufficiency." Acta clinica Croatica, vol. 55, br. 4., 2016, str. 629-635. https://doi.org/10.20471/acc.2016.55.04.14. Citirano 24.07.2019.
Chicago 17th Edition
Franić-Ivanišević, Maja, Damir Franić, Miomira Ivović, Milina Tančić-Gajić, Ljiljana Marina, Marija Barac i Svetlana Vujović. "Genetic etiology of primary premature ovarian insufficiency." Acta clinica Croatica 55, br. 4. (2016): 629-635. https://doi.org/10.20471/acc.2016.55.04.14
Harvard
Franić-Ivanišević, M., et al. (2016). 'Genetic etiology of primary premature ovarian insufficiency', Acta clinica Croatica, 55(4.), str. 629-635. https://doi.org/10.20471/acc.2016.55.04.14
Vancouver
Franić-Ivanišević M, Franić D, Ivović M, Tančić-Gajić M, Marina Lj, Barac M i sur. Genetic etiology of primary premature ovarian insufficiency. Acta clinica Croatica [Internet]. 2016 [pristupljeno 24.07.2019.];55(4.):629-635. https://doi.org/10.20471/acc.2016.55.04.14
IEEE
M. Franić-Ivanišević, et al., "Genetic etiology of primary premature ovarian insufficiency", Acta clinica Croatica, vol.55, br. 4., str. 629-635, 2016. [Online]. https://doi.org/10.20471/acc.2016.55.04.14

Sažetak
Primary premature ovarian insufficiency (PPOI) is characterized by hypergonadotropic amenorrhea and hypoestrogenism in women under 40 years of age. PPOI incidence is 1:10,000 in women aged 18-25, 1:1000 in women aged 25-30 and 1:100 in women aged 35-40. In 10%-28% of cases, PPOI causes primary and in 4%-18% secondary amenorrhea. The process is a consequence of accelerated oocyte atresia, diminished number of germinated cells, and central nervous system aging. Specific genes are responsible for the control of oocyte number undergoing the ovulation process and the time to cessation of the reproductive function. A positive family history of PPOI is found in 15% of women with PPOI, indicating the existing genetic etiology. Primary POI comprises genetic aberrations linked to chromosome X (monosomy, trisomy, translocation, deletion) or to autosomal chromosome. Secondary POI implies surgical removal of ovaries, chemotherapy and radiotherapy, and infections. Diagnostic criteria include follicle stimulating hormone level >40 IU/L and estradiol level
<50 pmol/L.

Ključne riječi
Primary ovarian insufficiency – etiology; Primary ovarian insufficiency – genetics

Hrčak ID: 178101

URI
https://hrcak.srce.hr/178101

[hrvatski]

Posjeta: 641 *