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Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma

Nives Jonjić ; Department of Pathology, University of Rijeka, Clinical Hospital Center Rijeka
Koraljka Rajković Molek ; Department of Cytology, University of Rijeka, Clinical Hospital Center Rijeka
Irena Seili-Bekafigo ; Department of Cytology, University of Rijeka, Clinical Hospital Center Rijeka
Svjetlana Grbac-Ivanković ; Department of Nuclear Medicine, Clinical Hospital Center Rijeka, University of Rijeka
Neva Girotto ; Department of Nuclear Medicine, Clinical Hospital Center Rijeka, University of Rijeka
Davor Jurišić ; Department of Surgery, Clinical Hospital Center Rijeka, University of Rijeka
Gordana Zamolo ; Department of Pathology, University of Rijeka, Clinical Hospital Center Rijeka
Ira Pavlović-Ružić ; Department of Oncology, Clinical Hospital Center Rijeka, University of Rijeka
Larisa Prpić-Massari ; Department of Dermatovenerology, Clinical Hospital Center Rijeka, University of Rijeka

Puni tekst: engleski, PDF (187 KB) str. 99-99 preuzimanja: 80* citiraj
APA 6th Edition
Jonjić, N., Rajković Molek, K., Seili-Bekafigo, I., Grbac-Ivanković, S., Girotto, N., Jurišić, D., ... Prpić-Massari, L. (2017). Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma. Acta dermatovenerologica Croatica, 25 (2), 99-99. Preuzeto s https://hrcak.srce.hr/185015
MLA 8th Edition
Jonjić, Nives, et al. "Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma." Acta dermatovenerologica Croatica, vol. 25, br. 2, 2017, str. 99-99. https://hrcak.srce.hr/185015. Citirano 19.10.2019.
Chicago 17th Edition
Jonjić, Nives, Koraljka Rajković Molek, Irena Seili-Bekafigo, Svjetlana Grbac-Ivanković, Neva Girotto, Davor Jurišić, Gordana Zamolo, Ira Pavlović-Ružić i Larisa Prpić-Massari. "Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma." Acta dermatovenerologica Croatica 25, br. 2 (2017): 99-99. https://hrcak.srce.hr/185015
Harvard
Jonjić, N., et al. (2017). 'Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma', Acta dermatovenerologica Croatica, 25(2), str. 99-99. Preuzeto s: https://hrcak.srce.hr/185015 (Datum pristupa: 19.10.2019.)
Vancouver
Jonjić N, Rajković Molek K, Seili-Bekafigo I, Grbac-Ivanković S, Girotto N, Jurišić D i sur. Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma. Acta Dermatovenerol Croat. [Internet]. 2017 [pristupljeno 19.10.2019.];25(2):99-99. Dostupno na: https://hrcak.srce.hr/185015
IEEE
N. Jonjić, et al., "Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma", Acta dermatovenerologica Croatica, vol.25, br. 2, str. 99-99, 2017. [Online]. Dostupno na: https://hrcak.srce.hr/185015. [Citirano: 19.10.2019.]

Sažetak

Since there are no standardized protocols regarding the detection of microscopic melanoma deposits in sentinel lymph nodes (SLN), the aim of this study was to present our experience with intraoperative cytological evaluation of SLN in patients with melanoma. The study included 475 SLN biopsies (SLNB) from 201 patients with primary cutaneous melanoma of intermediate thickness. Each lymph node was cut in half; touch imprint cytology (TIC) preparations of all cut surfaces were performed and stained according to a modified May-Grünwald-Giemsa method. The results were compared to definitive postoperative histology. Twenty of 25 SLNB positive on TIC proved to be metastatic when compared to definitive histology. Most of 32 SLN that were suspicious but not diagnostic on TIC were proven negative (23/32, 71.8%), while 7 nodes had metastases (one micrometastasis and one with isolated tumor cells only). The majority (94%) of SLNBs negative on TIC remained negative on final histology, while 6% or 25 nodes were positive, mostly with micrometastases or isolated tumor cells (17/25). In frozen sections performed in cases of suspicious or positive SLN cytology, metastasis was confirmed in 80% of positive and in 21.9% of suspicious TIC. Altogether, 49% (27/55) of positive SLNB were identified intraoperatively in 57% (24/42) of patients, and in those cases a complete regional lymph node dissection was performed in the first step. TIC assessment of SLNB with 99% specificity and 57% sensitivity for intraoperative identification of metastasis is useful and beneficial for avoiding a second operative procedure.

 

Ključne riječi
sentinel lymph node biopsy; touch imprint cytology; melanoma; intraoperative

Hrčak ID: 185015

URI
https://hrcak.srce.hr/185015

Posjeta: 187 *