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Comparison of doxycycline and benzathine penicillin G for the treatment of early syphilis

Hailu Xiao ; University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China
Dianchang Liu ; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Zhen Li ; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Rongtao Zheng ; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Zhongwei Li ; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Jianling Hou ; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Shengjia Zhang ; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Tongsheng Chu ; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Hongqing Tian ; 1 University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China 2 Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Furen Zhang ; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China

Puni tekst: engleski, PDF (180 KB) str. 107-107 preuzimanja: 344* citiraj
APA 6th Edition
Xiao, H., Liu, D., Li, Z., Zheng, R., Li, Z., Hou, J., ... Zhang, F. (2017). Comparison of doxycycline and benzathine penicillin G for the treatment of early syphilis. Acta Dermatovenerologica Croatica, 25 (2), 107-107. Preuzeto s https://hrcak.srce.hr/185016
MLA 8th Edition
Xiao, Hailu, et al. "Comparison of doxycycline and benzathine penicillin G for the treatment of early syphilis." Acta Dermatovenerologica Croatica, vol. 25, br. 2, 2017, str. 107-107. https://hrcak.srce.hr/185016. Citirano 26.10.2021.
Chicago 17th Edition
Xiao, Hailu, Dianchang Liu, Zhen Li, Rongtao Zheng, Zhongwei Li, Jianling Hou, Shengjia Zhang, Tongsheng Chu, Hongqing Tian i Furen Zhang. "Comparison of doxycycline and benzathine penicillin G for the treatment of early syphilis." Acta Dermatovenerologica Croatica 25, br. 2 (2017): 107-107. https://hrcak.srce.hr/185016
Harvard
Xiao, H., et al. (2017). 'Comparison of doxycycline and benzathine penicillin G for the treatment of early syphilis', Acta Dermatovenerologica Croatica, 25(2), str. 107-107. Preuzeto s: https://hrcak.srce.hr/185016 (Datum pristupa: 26.10.2021.)
Vancouver
Xiao H, Liu D, Li Z, Zheng R, Li Z, Hou J i sur. Comparison of doxycycline and benzathine penicillin G for the treatment of early syphilis. Acta Dermatovenerol Croat. [Internet]. 2017 [pristupljeno 26.10.2021.];25(2):107-107. Dostupno na: https://hrcak.srce.hr/185016
IEEE
H. Xiao, et al., "Comparison of doxycycline and benzathine penicillin G for the treatment of early syphilis", Acta Dermatovenerologica Croatica, vol.25, br. 2, str. 107-107, 2017. [Online]. Dostupno na: https://hrcak.srce.hr/185016. [Citirano: 26.10.2021.]

Sažetak

Doxycycline is the preferred recommended second-line treatment for the treatment of early syphilis. Recent reports showed a declining efficacy trend of doxycycline in treatment of early syphilis. The aim of our study was to assess the serological response to the treatment for early syphilis with doxycycline compared with benzathine penicillin G and evaluate whether doxycycline is still an effective agent for the treatment of early syphilis. A record-based retrospective study was conducted. Patients were diagnosed with early syphilis in an sexually transmitted disease (STD) clinic from January 1, 2008 to December 31, 2014. They were treated with a single dose of benzathine penicillin G 2.4MU or oral doxycycline 100 mg twice daily for 14 days. Pearson’s chi-squared test was used for data analysis. 601 cases were included in the final study sample: 105 (17.5%) patients received a 14-day course of doxycycline (doxycycline group), and 496 (82.5%) patients received single-dose benzathine penicillin G (BPG group). The serological responses at 6 months and 12 months after treatment were compared. No statistically significant differences were found between the two groups at 6 months (69.52% vs. 75.00%, P=0.245), and at 12 months (92.38% vs. 96.17%, P=0.115). Doxycycline is still an effective agent for the treatment of early syphilis.

 

Hrčak ID: 185016

URI
https://hrcak.srce.hr/185016

Posjeta: 682 *