Pregledni rad
https://doi.org/10.26332/seemedj.v1i1.35
Intrinsic Control and Environmental Factors in Food Consumption Related to Obesity
Ivana Jukić
; Department of Physiology and Immunology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Aleksandar Kibel
; Department of Physiology and Immunology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department for Cardiovascular Diseases, Osijek University Hospital, Osijek, Croatia
Dijana Kibel
; Department of Physiology and Immunology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Diagnostic and Interventional Radiology, Osijek University Hospital, Osijek, Croatia
Ines Drenjančević
; Department of Physiology and Immunology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Sažetak
Obesity results from a complex interaction of genetic, hormonal, physiological, anatomical, psychological, behavioral and environmental factors causing an imbalance between energy intake and energy expenditure. According to the World Health Organization,the estimated number of obese people around the world has doubled from 1980, meaning that more than 600 million people worldwide are obese.
Obesity is associated with low-level chronic inflammation and representsa major risk factor for cardiovascular and metabolic diseases, but also some cancers.Centers that regulate food intake and energy balance are placed in the hypothalamus. Chemical signals are transmitted between hypothalamic neurons, and those neurons also affect the secretion of different hormones that are important for maintaining energy balance and metabolism. Moreover, genetic predisposition is also a risk factor for obesity development. Key neuronal populations for maintaining energy balance are the orexigenic agouti related peptide (AgRP)/neuropeptide Y (NPY) neurons and the anorexigenic proopiomelanocortin (POMC) neurons.This review attempts to present the prevalence and the major pathways regulating energy balance that may be affected by many environmental and social factors, such as emotions and human behavior, and can lead to obesity.
Ključne riječi
obesity; POMC; melanocortins; chronic stress; social behavior
Hrčak ID:
186757
URI
Datum izdavanja:
3.7.2017.
Posjeta: 1.108 *