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In vitro antimicrobial susceptibility of Ureaplasma urealyticum
; Opća županijska bolnica Požega, Odjel infektologije
; Opća županijska bolnica Požega, Odjel mikrobiologije
; Opća županijska bolnica Požega, Odjel za neurologiju
; Ordinacija obiteljske medicine, Požega
Puni tekst: hrvatski, pdf (394 KB)
Petković, D., Cviljević, S., Vuković, B., Musil, A. (2017). In vitro antimikrobna osjetljivost Ureaplasma urealyticum. Medica Jadertina, 47(3-4), 145-152. Preuzeto s https://hrcak.srce.hr/187200
Introduction. Ureaplasma urealyticum is the commensal of the lower genitourinary tract and causes sexually transmitted diseases. Antimicrobial resistance to tetracyclines and macrolides is low, and to quinolones high.
Objective. To determine and compare the prevalence and in vitro antimicrobial susceptibility of U. urealyticum in urogenital samples of women of reproductive age in the period from June 2005 to June 2006 and in 2015.
Materials and methods. In the period from June 2005 to June 2006 in vitro antimicrobial susceptibility of U. urealyticum from urogenital samples of 72 female patients with urethral syndrome were evaluated and the results were compared with 181 isolates of U. Urealyticum from the genitourinary tract of patients with gynaecological issues in year 2015. The U. urealyticum. Mycoplasma IST 2 kit was used for identification. Invitro antimicrobial susceptibility of the isolates high concentrations ≥ 104 CCU / ml was determined by the dilution method in broth to 7 antibiotics: doxycycline, tetracycline, azithromycin, erythromycin, clarythromycin, ciprofloxacin, ofloxacin.
Results. In 2005/2006, the prevalence of U. urealyticum in women of reproductive age was 28% and 22.7% in 2015 (p = 0.516). The results in vitro antimicrobial susceptibility in the period from June 2005 to June 2006 and in 2015 were the following: sensitivity to doxycycline 100% and 97.8%, tetracycline 100% and 97.8%, clarithromycin 93.7% and 89.5%, erythromycin 90.3% and 85.6%, azithromycin 87% and 81.2%, ofloxacin 62 and 59.7%, ciprofloxacin 40.3% and 28.9%. Low rate of resistance to doxycycline and tetracyclines (2.2%) and the macrolides (clarithromycin 6.3% and 10.5%; erythromycin 9.7% and 14.4%; azithromycin 13% and 18.8%) and high to quinolones (ofloxacin 38% and 40.3%; ciprofloxacin 59% and 71.1%) was registered, and there were not statistically significant differences in resistance.
Conclusion. In our study, statistically significant differences in the prevalence of U. urealyticum in women of reproductive age in were not registered in the observed period. The results in vitro antimicrobial susceptibility of U. urealyticum show a trend of increasing resistance but there were no statistically significant differences. Despite the high sensitivity of U. urealyticum to tetracyclines and macrolides as a first-line treatment, due to the trend of increasing resistance, it is necessary to continuously monitor in vitro antimicrobial susceptibility in the local region for the purpose of an adequate choice of antibiotics.
ureaplasma urealyticum; antimicrobial susceptibility in vitro
Hrčak ID: 187200
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