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HLA-E*0101/0103X is associated with susceptibility to pemphigus vulgaris: a case-control study

Ece Altun ; Dept of DermatologyKaradeniz Technical University
Savas Yayli ; Dept of DermatologyKaradeniz Technical University
Bayram Toraman ; Dept of Medical BiologyKaradeniz Technical University
Deniz Aksu Arica ; Dept of DermatologyKaradeniz Technical University
Ersan Kalay ; Dept of Medical BiologyKaradeniz Technical University
Leyla Baykal Selçuk ; Dept of DermatologyKaradeniz Technical University
Sevgi Bahadir ; Dept of DermatologyKaradeniz Technical University

Fulltext: english, PDF (116 KB) pages 189-189 downloads: 182* cite
APA 6th Edition
Altun, E., Yayli, S., Toraman, B., Aksu Arica, D., Kalay, E., Baykal Selçuk, L. & Bahadir, S. (2017). HLA-E*0101/0103X is associated with susceptibility to pemphigus vulgaris: a case-control study. Acta Dermatovenerologica Croatica, 25 (3), 189-189. Retrieved from https://hrcak.srce.hr/187813
MLA 8th Edition
Altun, Ece, et al. "HLA-E*0101/0103X is associated with susceptibility to pemphigus vulgaris: a case-control study." Acta Dermatovenerologica Croatica, vol. 25, no. 3, 2017, pp. 189-189. https://hrcak.srce.hr/187813. Accessed 3 Dec. 2021.
Chicago 17th Edition
Altun, Ece, Savas Yayli, Bayram Toraman, Deniz Aksu Arica, Ersan Kalay, Leyla Baykal Selçuk and Sevgi Bahadir. "HLA-E*0101/0103X is associated with susceptibility to pemphigus vulgaris: a case-control study." Acta Dermatovenerologica Croatica 25, no. 3 (2017): 189-189. https://hrcak.srce.hr/187813
Harvard
Altun, E., et al. (2017). 'HLA-E*0101/0103X is associated with susceptibility to pemphigus vulgaris: a case-control study', Acta Dermatovenerologica Croatica, 25(3), pp. 189-189. Available at: https://hrcak.srce.hr/187813 (Accessed 03 December 2021)
Vancouver
Altun E, Yayli S, Toraman B, Aksu Arica D, Kalay E, Baykal Selçuk L, et al. HLA-E*0101/0103X is associated with susceptibility to pemphigus vulgaris: a case-control study. Acta Dermatovenerol Croat. [Internet]. 2017 [cited 2021 December 03];25(3):189-189. Available from: https://hrcak.srce.hr/187813
IEEE
E. Altun, et al., "HLA-E*0101/0103X is associated with susceptibility to pemphigus vulgaris: a case-control study", Acta Dermatovenerologica Croatica, vol.25, no. 3, pp. 189-189, 2017. [Online]. Available: https://hrcak.srce.hr/187813. [Accessed: 03 December 2021]

Abstracts

Pemphigus vulgaris (PV) is a life-threatening, autoimmune blistering disease of the skin and mucous membranes. The relationship between PV and human leukocyte antigen (HLA) has been studied in several reports. Previous reports have demonstrated that HLA-E polymorphisms may have a role in the susceptibility to various autoimmune diseases. Our aim was to evaluate the role of HLA-E gene polymorphisms in the pathogenesis of PV in a Turkish population. A total of 49 patients with PV and 50 healthy subjects were enrolled into the study. We sequenced and analyzed the HLA-E gene from genomic DNA obtained from peripheral blood samples of the study groups. HLA-E haplotyping was performed by Sanger sequencing of PCR products of the HLA-E gene and HLA-E alleles determined by using SeqScape® software according to the World Health Organization (WHO) Nomenclature Committee for Factors of the HLA System. The frequency of the HLA-E*0101/*0103X genotype in male patients with PV was found to be significantly higher than in men in the control group (P=0.023). In addition, the frequency of the HLA-E*0103X/*0103X genotype was significantly lower in patients with PV than the control group (P=0.040). We also detected that the frequency of the HLA-E*0101/*0103X genotype in patients with mucocutaneous type PV and the frequency of the HLA-E*0101/*0101 genotype in patients with mucosal type PV was significantly higher than those in other types of PV (P=0.001 and P=0.006). The results of this study indicate that carrying the HLA-E*0101/0103X genotype may increase the risk of PV in male patients.

 

Keywords
Pemphigus; hla-e; genetics

Hrčak ID: 187813

URI
https://hrcak.srce.hr/187813

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