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Porphyrinuria as early sign of dangerous lead absorption
Ibrahim Ruždić
; Institut za higijenu rada Zagreb
Sažetak
Each lead poisoning causes an increased excretion of coproporphyrine, isomer III. Some authors tried to use this fact for an early detection of dangerous lead absorptions. However, the method recommended by them did not vouchsafe for detecting the beginning of dangerous absorptions. But such a detection would be a much more useful reliable laboratory weapon for estimating various forms of lead intoxication than that of »stippled" erythrocytes. On the basis of experience acquired in a series of investigations we proceeded to use for this purpose our semiquantitative method for detecting coproporphyrine in urine. We thus succeeded in bypassing the difficulties described by the above-named authors. We were able to observe already the first small changes, in the amount of coproporphyrine excreted in urine and caused by increased lead absorption. Data on ascertaintment of coproporphyrine in urine in 53 workers prove that the phenomenon of dangerous lead absorption in the organism·can be observed in this way.
Ključne riječi
Hrčak ID:
189409
URI
Datum izdavanja:
26.9.1950.
Posjeta: 761 *