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Transferrin in health and disease

Tatjana Belovari
Aleksandar Kibel
Ljiljana Kostović-Knežević


Puni tekst: hrvatski pdf 126 Kb

str. 21-24

preuzimanja: 1.592

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Puni tekst: engleski pdf 126 Kb

str. 21-24

preuzimanja: 157

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Sažetak

Transferrin is an iron-binding glycoprotein, secreted by different cells in the body, important in the regulation of iron metabolism and homeostasis, and functioning as a growth factor - both in embryonic development, as well as in tumor growth. It could also be used for drug delivery to certain cells. By interaction with transferrin receptors, and subsequent endocytosis, transferrin is entering cells. After releasing iron, the complex recycles back to the surface. The transferrin/transferrin receptor system is also connected with some disorders, including atransferrinemia, hypotransferrinemia, hereditary hemochromatosis, and probably even neurodegenerative diseases.

Ključne riječi

Transferrin; Transferrin receptor; Iron; Growth factor

Hrčak ID:

191048

URI

https://hrcak.srce.hr/191048

Datum izdavanja:

1.12.2006.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.368 *