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Arhiv za higijenu rada i toksikologiju, Vol. 68 No. 4, 2017.

Pregledni rad
https://doi.org/10.1515/aiht-2017-68-3054

How protein coronas determine the fate of engineered nanoparticles in biological environment

Ivona Capjak ; Croatian Institute of Transfusion Medicine, Zagreb, Croatia
Sandra Šupraha Goreta ; University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
Darija Domazet Jurašin   ORCID icon orcid.org/0000-0001-5261-5961 ; Ruđer Bošković Institute, Zagreb, Croatia
Ivana Vinković Vrček   ORCID icon orcid.org/0000-0003-1382-5581 ; Institute for Medical Research and Occupational Health, Zagreb, Croatia

Puni tekst: engleski, pdf (851 KB) str. 245-252 preuzimanja: 292* citiraj
APA 6th Edition
Capjak, I., Šupraha Goreta, S., Domazet Jurašin, D. i Vinković Vrček, I. (2017). How protein coronas determine the fate of engineered nanoparticles in biological environment. Arhiv za higijenu rada i toksikologiju, 68 (4), 245-252. https://doi.org/10.1515/aiht-2017-68-3054
MLA 8th Edition
Capjak, Ivona, et al. "How protein coronas determine the fate of engineered nanoparticles in biological environment." Arhiv za higijenu rada i toksikologiju, vol. 68, br. 4, 2017, str. 245-252. https://doi.org/10.1515/aiht-2017-68-3054. Citirano 16.02.2019.
Chicago 17th Edition
Capjak, Ivona, Sandra Šupraha Goreta, Darija Domazet Jurašin i Ivana Vinković Vrček. "How protein coronas determine the fate of engineered nanoparticles in biological environment." Arhiv za higijenu rada i toksikologiju 68, br. 4 (2017): 245-252. https://doi.org/10.1515/aiht-2017-68-3054
Harvard
Capjak, I., et al. (2017). 'How protein coronas determine the fate of engineered nanoparticles in biological environment', Arhiv za higijenu rada i toksikologiju, 68(4), str. 245-252. doi: https://doi.org/10.1515/aiht-2017-68-3054
Vancouver
Capjak I, Šupraha Goreta S, Domazet Jurašin D, Vinković Vrček I. How protein coronas determine the fate of engineered nanoparticles in biological environment. Arh Hig Rada Toksikol. [Internet]. 2017 [pristupljeno 16.02.2019.];68(4):245-252. doi: https://doi.org/10.1515/aiht-2017-68-3054
IEEE
I. Capjak, S. Šupraha Goreta, D. Domazet Jurašin i I. Vinković Vrček, "How protein coronas determine the fate of engineered nanoparticles in biological environment", Arhiv za higijenu rada i toksikologiju, vol.68, br. 4, str. 245-252, 2017. [Online]. doi: https://doi.org/10.1515/aiht-2017-68-3054

Sažetak
Nanomedicine is a booming medical field that utilises nanoparticles (NPs) for the development of medicines, medical devices, and diagnostic tools. The behaviour of NPs in vivo may be quite complex due to their interactions with biological molecules. These interactions in biological fluids result in NPs being enveloped by dynamic protein coronas, which serve as an interface between NPs and their environment (blood, cell, tissue). How will the corona interact with this environment will depend on the biological, chemical, and physical properties of NPs, the properties of the proteins that make the corona, as well as the biological environment. This review summarises the main characteristics of protein corona and describes its dynamic nature. It also presents the most common analytical methods to study the corona, including examples of protein corona composition for the most common NPs used in biomedicine. This knowledge is necessary to design NPs that will create a corona with a desired efficiency and safety in clinical use.

Ključne riječi
hard corona; nano-bio interface; nanomedicine; soft corona

Hrčak ID: 191058

URI
https://hrcak.srce.hr/191058

[hrvatski]

Posjeta: 392 *