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Arhiv za higijenu rada i toksikologiju, Vol. 68 No. 4, 2017.

Izvorni znanstveni članak
https://doi.org/10.1515/aiht-2017-68-2974

Salivary sCD14 as a potential biomarker of dental caries activity in adults

Ljerka Prester ; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Nives Protrka ; Private dental practice, Zagreb, Croatia
Jelena Macan ; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Marina Katunarić ; Zagreb University School of Dental Medicine, Zagreb, Croatia

Puni tekst: engleski, pdf (284 KB) str. 315-320 preuzimanja: 90* citiraj
APA 6th Edition
Prester, Lj., Protrka, N., Macan, J. i Katunarić, M. (2017). Salivary sCD14 as a potential biomarker of dental caries activity in adults. Arhiv za higijenu rada i toksikologiju, 68 (4), 315-320. https://doi.org/10.1515/aiht-2017-68-2974
MLA 8th Edition
Prester, Ljerka, et al. "Salivary sCD14 as a potential biomarker of dental caries activity in adults." Arhiv za higijenu rada i toksikologiju, vol. 68, br. 4, 2017, str. 315-320. https://doi.org/10.1515/aiht-2017-68-2974. Citirano 23.02.2019.
Chicago 17th Edition
Prester, Ljerka, Nives Protrka, Jelena Macan i Marina Katunarić. "Salivary sCD14 as a potential biomarker of dental caries activity in adults." Arhiv za higijenu rada i toksikologiju 68, br. 4 (2017): 315-320. https://doi.org/10.1515/aiht-2017-68-2974
Harvard
Prester, Lj., et al. (2017). 'Salivary sCD14 as a potential biomarker of dental caries activity in adults', Arhiv za higijenu rada i toksikologiju, 68(4), str. 315-320. doi: https://doi.org/10.1515/aiht-2017-68-2974
Vancouver
Prester Lj, Protrka N, Macan J, Katunarić M. Salivary sCD14 as a potential biomarker of dental caries activity in adults. Arh Hig Rada Toksikol. [Internet]. 2017 [pristupljeno 23.02.2019.];68(4):315-320. doi: https://doi.org/10.1515/aiht-2017-68-2974
IEEE
Lj. Prester, N. Protrka, J. Macan i M. Katunarić, "Salivary sCD14 as a potential biomarker of dental caries activity in adults", Arhiv za higijenu rada i toksikologiju, vol.68, br. 4, str. 315-320, 2017. [Online]. doi: https://doi.org/10.1515/aiht-2017-68-2974

Sažetak
CD14 is a co-receptor involved in the recognition of Gram-negative and Gram-positive bacteria, the latter known to cause dental caries. The aim of this study was to determine whether soluble CD14 (sCD14) in saliva was associated with caries activity and the collection method from the saliva. The study included 55 participants aged 20 to 40 years, 30 with dental caries and 25 caries-free controls. We collected 110 saliva samples in total, 55 of resting saliva and 55 of mechanically stimulated saliva. Median levels of sCD14, measured with a matrix-matched enzyme-linked immunosorbent assay (ELISA), were higher in the caries-active than in the caries-free group in either resting (203.3 vs.167.9 ng mL-1; P<0.01) or stimulated saliva (201 vs.105.7 ng mL-1; P<0.01). The resting salivary flow rate was lower in the caries-active than caries-free group (0.61±0.42 vs. 0.98±0.52 mL min -1; P<0.01). Hyposalivation was observed only in the caries-active group (10 and 13 % in stimulated and resting saliva, respectively). Higher salivary sCD14 levels and secretion rates were clearly associated with dental caries and resting saliva. Future studies should focus on the clinical utility of salivary sCD14 as a potential biomarker and predictor of future caries events.

Ključne riječi
ELISA; hyposalivation; resting saliva; salivary flow rate; stimulated saliva

Hrčak ID: 191146

URI
https://hrcak.srce.hr/191146

[hrvatski]

Posjeta: 174 *