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https://doi.org/10.20471/acc.2017.56.03.02

Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions

Lindita Zendeli-Bedjeti ; Department of Oral Pathology and Periodontology, St. Panteleimon University Dental Clinical Center, Skopje, Republic of Macedonia
Mirjana Popovska ; Department of Oral Pathology and Periodontology, St. Panteleimon University Dental Clinical Center, Skopje, Republic of Macedonia ;School of Dental Medicine, Skopje, Republic of Macedonia
Aneta Atanasovska-Stojanovska   ORCID icon orcid.org/0000-0003-0191-4923 ; Department of Oral Pathology and Periodontology, St. Panteleimon University Dental Clinical Center, Skopje, Republic of Macedonia ;School of Dental Medicine, Skopje, Republic of Macedonia
Sotirija Duvlis ; Institute of Public Health, Skopje, Republic of Macedonia

Puni tekst: engleski, pdf (101 KB) str. 369-374 preuzimanja: 317* citiraj
APA 6th Edition
Zendeli-Bedjeti, L., Popovska, M., Atanasovska-Stojanovska, A. i Duvlis, S. (2017). Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions. Acta clinica Croatica, 56. (3.), 369-374. https://doi.org/10.20471/acc.2017.56.03.02
MLA 8th Edition
Zendeli-Bedjeti, Lindita, et al. "Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions." Acta clinica Croatica, vol. 56., br. 3., 2017, str. 369-374. https://doi.org/10.20471/acc.2017.56.03.02. Citirano 20.06.2021.
Chicago 17th Edition
Zendeli-Bedjeti, Lindita, Mirjana Popovska, Aneta Atanasovska-Stojanovska i Sotirija Duvlis. "Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions." Acta clinica Croatica 56., br. 3. (2017): 369-374. https://doi.org/10.20471/acc.2017.56.03.02
Harvard
Zendeli-Bedjeti, L., et al. (2017). 'Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions', Acta clinica Croatica, 56.(3.), str. 369-374. https://doi.org/10.20471/acc.2017.56.03.02
Vancouver
Zendeli-Bedjeti L, Popovska M, Atanasovska-Stojanovska A, Duvlis S. Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions. Acta clinica Croatica [Internet]. 2017 [pristupljeno 20.06.2021.];56.(3.):369-374. https://doi.org/10.20471/acc.2017.56.03.02
IEEE
L. Zendeli-Bedjeti, M. Popovska, A. Atanasovska-Stojanovska i S. Duvlis, "Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions", Acta clinica Croatica, vol.56., br. 3., str. 369-374, 2017. [Online]. https://doi.org/10.20471/acc.2017.56.03.02

Sažetak
Oral premalignant lesions (OPLs) and numerous alterations of oral mucosa remain unsolved due to their complex etiopathogenesis. Human papillomaviruses (HPVs), in particular, have been reported as the possible risk factors or cofactors. The aim of the study was to determine the association of different HPV types with oral premalignant lesions, and the potential role of smoking and alcohol use. Eighty patients (mean age ± SD, 52.45±5.56) of both genders, 19 (23.75%) male and 61 (76.25%) female, were enrolled in the study. Study group included 40 patients diagnosed with OPLs (leukoplakia, erythroplakia, actinic keratosis and lichen planus), while control group included another 40 patients with healthy oral mucosa. Genotyping of the HPV types was performed by qualitative real-time HPV typing polymerase chain reaction test. HPV DNA was detected in 30% (12/40) of study group patients and 2.5% (1/40) of control group patients. The results revealed the presence of HPV16 in 15% (6/40), HPV56 in 10% (4/40), and HPV18 in 5% (2/40) of study group cases, and HPV31 in 1 (2.5%) control group patient. Th e association of oral HPV positivity and smoking/alcohol use in the study group was not statistically signifi cant (p>0.05). In conclusion, high-risk HPV types are associated with oral premalignant disorders. However, it remains unknown whether HPV acts as an innocent bystander or it has a role in initiating development of premalignant lesions. Smoking and alcohol use were not associated with the existing oral HPV infection.

Ključne riječi
Mouth diseases; Papillomaviridae; Human papillomavirus 16; Polymerase chain reaction; Macedonia

Hrčak ID: 191180

URI
https://hrcak.srce.hr/191180

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