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In vivo Effects of Maternal Immunosupression during Pregnancy on the Immune Function of Newborn Infants

Elisa Meregalli
Martina Biggioggero
Orietta Borghi
Pierluigi Meroni
Rolando Cimaz

Puni tekst: engleski, pdf (119 KB) str. 151-156 preuzimanja: 1.003* citiraj
APA 6th Edition
Meregalli, E., Biggioggero, M., Borghi, O., Meroni, P. i Cimaz, R. (2005). In vivo Effects of Maternal Immunosupression during Pregnancy on the Immune Function of Newborn Infants. Arhiv za higijenu rada i toksikologiju, 56 (2), 151-156. Preuzeto s https://hrcak.srce.hr/143
MLA 8th Edition
Meregalli, Elisa, et al. "In vivo Effects of Maternal Immunosupression during Pregnancy on the Immune Function of Newborn Infants." Arhiv za higijenu rada i toksikologiju, vol. 56, br. 2, 2005, str. 151-156. https://hrcak.srce.hr/143. Citirano 17.06.2019.
Chicago 17th Edition
Meregalli, Elisa, Martina Biggioggero, Orietta Borghi, Pierluigi Meroni i Rolando Cimaz. "In vivo Effects of Maternal Immunosupression during Pregnancy on the Immune Function of Newborn Infants." Arhiv za higijenu rada i toksikologiju 56, br. 2 (2005): 151-156. https://hrcak.srce.hr/143
Harvard
Meregalli, E., et al. (2005). 'In vivo Effects of Maternal Immunosupression during Pregnancy on the Immune Function of Newborn Infants', Arhiv za higijenu rada i toksikologiju, 56(2), str. 151-156. Preuzeto s: https://hrcak.srce.hr/143 (Datum pristupa: 17.06.2019.)
Vancouver
Meregalli E, Biggioggero M, Borghi O, Meroni P, Cimaz R. In vivo Effects of Maternal Immunosupression during Pregnancy on the Immune Function of Newborn Infants. Arh Hig Rada Toksikol. [Internet]. 2005 [pristupljeno 17.06.2019.];56(2):151-156. Dostupno na: https://hrcak.srce.hr/143
IEEE
E. Meregalli, M. Biggioggero, O. Borghi, P. Meroni i R. Cimaz, "In vivo Effects of Maternal Immunosupression during Pregnancy on the Immune Function of Newborn Infants", Arhiv za higijenu rada i toksikologiju, vol.56, br. 2, str. 151-156, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/143. [Citirano: 17.06.2019.]

Sažetak
When used in pregnancy, immunosuppressants can cross the placental barrier and enter foetal circulation, possibly affecting the immune system of the foetus. This study evaluated the immune function in eight children born by mothers with connective tissue diseases who received immunosuppressants (cyclosporine A or dexamethasone) during pregnancy and in six babies from mothers with similar diseases, but who did not receive any treatment. Judging by the cytokine production of interleukin-2 and interferon-γ in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies.

Ključne riječi
cyclosporine A; dexamethasone; immune function; immunosuppressants; newborns; vaccination

Hrčak ID: 143

URI
https://hrcak.srce.hr/143

[hrvatski]

Posjeta: 1.313 *