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Original scientific paper
https://doi.org/10.2478/v10007-007-0047-z

A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol

IBRAHIM A. DARWISH
SAMIHA A. HUSSEIN
ASHRAF M. MAHMOUD
AHMED I. HASSAN

Fulltext: english, pdf (89 KB) pages 87-97 downloads: 1.369* cite
APA 6th Edition
DARWISH, I.A., HUSSEIN, S.A., MAHMOUD, A.M. & HASSAN, A.I. (2008). A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol. Acta Pharmaceutica, 58 (1), 87-97. https://doi.org/10.2478/v10007-007-0047-z
MLA 8th Edition
DARWISH, IBRAHIM A., et al. "A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol." Acta Pharmaceutica, vol. 58, no. 1, 2008, pp. 87-97. https://doi.org/10.2478/v10007-007-0047-z. Accessed 19 Oct. 2019.
Chicago 17th Edition
DARWISH, IBRAHIM A., SAMIHA A. HUSSEIN, ASHRAF M. MAHMOUD and AHMED I. HASSAN. "A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol." Acta Pharmaceutica 58, no. 1 (2008): 87-97. https://doi.org/10.2478/v10007-007-0047-z
Harvard
DARWISH, I.A., et al. (2008). 'A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol', Acta Pharmaceutica, 58(1), pp. 87-97. https://doi.org/10.2478/v10007-007-0047-z
Vancouver
DARWISH IA, HUSSEIN SA, MAHMOUD AM, HASSAN AI. A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol. Acta Pharm. [Internet]. 2008 [cited 2019 October 19];58(1):87-97. https://doi.org/10.2478/v10007-007-0047-z
IEEE
I.A. DARWISH, S.A. HUSSEIN, A.M. MAHMOUD and A.I. HASSAN, "A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol", Acta Pharmaceutica, vol.58, no. 1, pp. 87-97, 2008. [Online]. https://doi.org/10.2478/v10007-007-0047-z

Abstracts
A simple, accurate and sensitive spectrophotometric method for determination of H2-receptor antagonists: cimetidine (CIM), famotidine (FAM), nizatidine (NIZ), and ranitidine hydrochloride (RAN) has been full developed and validated The method was based on the reaction of these drugs with NBS and subsequent measurement of the excess N-bromosuccinimide by its reaction with p-aminophenol to give a violet colored product (max at 552 nm). Decrease in the absorption intensity (A) of the colored product, due to the presence of the drug, was correlated with its concentration in the sample solution. Different variables affecting the reaction were carefully studied and optimized. Under optimal conditions, linear relationships with good correlation coefficients (0.9988-0.9998) were found between A values and the corresponding concentrations of the drugs in a concentration range of 830, 622, 625, and 420 g mL1 for CIM, FAM, NIZ, and RAN, respectively. Limits of detection were 1.22, 1.01, 1.08, and 0.74 g mL1 for CIM, FAM, NIZ, and RAN, respectively. The method was validated in terms of accuracy, precision, ruggedness, and robustness; the results were satisfactory. The proposed method was successfully applied to the analysis of the above mentioned drugs in bulk substance and in pharmaceutical dosage forms; percent recoveries ranged from 98.5  0.9 to 102.4  0.8% without interference from the common excipients. The results obtained by the proposed method were comparable with those obtained by the official methods.

Keywords
H2-receptors antagonists; N-bromosuccinimide; p-aminophenol; spectrophotometry; pharmaceutical analysis

Hrčak ID: 18115

URI
https://hrcak.srce.hr/18115

[croatian]

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