Medicinski vjesnik, Vol. 30 No. (1-2), 1998.
Stručni rad
The effects of suppressive therapy of difuse euthyroid goitre with levothyroxine (comparation on effects in younger and middle-aged patients)
Ivica Mihaljević
Ivan Karner
Juraj Smoje
Sažetak
In a prospective study 67 patients with diffuse euthyroid goitre, between 17 and 21 years old (group I, n=28) and between 33 and 45 years old (group II, n=39), were treated for one year with 100 levothyroxine daily, have been evaluated effects of supressive therapy measured by sonography and palpation. After 3, 6, 9 and 12 months the reduction of the goitre volume was significantly different from the initial volume in both groups. In both forms of treatment maximum volume decrease was already seen within the first six months. After treatment for 6 months the mean decrease of thyroid volumes was 19.2% in group I and 28.6% in group II. After treatment for 12 months the mean decrease of thyroid volumes was 23.5% in group I and 32.3% in group II compared to the initial volume. In group I after 1 month (in group II after 2 months) a more significant increase of T4 and of fT4 values within the normal range was observed immediately after supressive therapy. There were no changes of the T3 and fT3 values. In both groups it has been found out that in the first 6 months and after 1 year therapy with levothyroxine exist a comparable efficiency for the reduction of goiters with statistically significant differences in favour group II.
Ključne riječi
diffuse euthyroid goitre; suppressive therapy; levothyroxine
Hrčak ID:
192075
URI
Datum izdavanja:
1.12.1998.
Posjeta: 734 *